SLC7A6

Gene Symbol	SLC7A6
Entrez Gene	9057
Alt Symbol	LAT-2, LAT3, y+LAT-2
Species	Human
Gene Type	protein-coding
Description	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
Other Description	Y+L amino acid transporter 2|amino acid permease|cationic amino acid transporter, y+ system|solute carrier family 7 (cationic amino acid transporter, y+ system), member 6|solute carrier family 7 member 6|y(+)L-type amino acid transporter 2|y+LAT2
Swissprots	Q92536 Q7L1N3 Q68DS4
Accessions	EAW83219 EAW83220 Q92536 AK310602 AK310866 AK311610 BC028216 AAH28216 BC113100 AAI13101 BP242589 CR749291 CAH18146 CR749475 CAH18305 D87432 BAA13376 DB107640 DQ891023 ABM81949 DQ894203 ABM85129 R48943 XM_011523433 XP_011521735 XM_011523434 XP_011521736 XM_011523435 XP_011521737 XM_011523436 XP_011521738 XM_011523437 XP_011521739 XM_011523438 XP_011521740 XM_011523439 XP_011521741 XR_243433 NM_001076785 NP_001070253 NM_003983 NP_003974
Function	Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. {ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974}.
Subcellular Location	Basolateral cell membrane {ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209}; Multi- pass membrane protein {ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209}.
Tissue Specificity	Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines. {ECO:0000269|PubMed:11078698, ECO:0000269|PubMed:11742806, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SLC7A6 (G-12) - sc-136884 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

SLC7A6 (N-12) - sc-136887 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-SLC7A6 antibody - ab103863 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A6 Antibody (C-Terminus, AP) - LS-C273808 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A6 Antibody (C-Terminus, APC) - LS-C273809 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A6 Antibody (C-Terminus, Biotin) - LS-C273810 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A6 Antibody (C-Terminus, FITC) - LS-C273811 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A6 Antibody (C-Terminus, PE) - LS-C273816 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A6 Antibody (C-Terminus, Azide-free, HRP) - LS-C273812 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A6 Antibody (C-Terminus) - LS-C326417 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC7A6 Antibody (aa487-515) - LS-C160688 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

SLC7A6 Antibody - NBP2-30868 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-YLAT2 (C-TERM) antibody produced in rabbit - SAB1301735 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC7A6 antibody produced in rabbit - HPA050713 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC7A6 Antibody - C-terminal region (OAAB02717) - OAAB02717 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

YLAT2-Antibody-C-term - AP5300b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

SLC7A6 antibody - H00009057-B01P from Acris Antibodies Prices $1,530.00 Sizes 500 µg Host Mouse Clonality Polyclonal

SLC7A6 antibody - 13823-1-AP from Proteintech Group Host Rabbit Clonality Polyclonal

YLAT2 Polyclonal Antibody - PA5-25223 from Thermo Fisher Scientific Prices $349.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

YLAT2, Polyclonal Antibody - MBS9207006 from MyBioSource Prices $155.00, $340.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

SLC7A6 Antibody / YLAT2 (R36480) - R36480 from NSJ Bioreagent Prices $299.00 Sizes 100 µg (0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide) Host Goat Clonality Polyclonal

SLC7A6 Antibody / YLAT2 (R36469) - R36469 from NSJ Bioreagent Prices $299.00 Sizes 100 µg (0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide) Host Goat Clonality Polyclonal

Anti-SLC7A6 antibody - STJ73470 from St John's Laboratory Ltd Host Goat Clonality Polyclonal

Anti-SLC7A6 antibody - STJ73471 from St John's Laboratory Ltd Host Goat Clonality Polyclonal

SLC7A6 Antibody,Biotin conjugated - CSB-PA849761LD01HU from Cusabio Host Rabbit Clonality Polyclonal

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