| Gene Symbol |
SLC7A6
|
| Entrez Gene |
9057
|
| Alt Symbol |
LAT-2, LAT3, y+LAT-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
|
| Other Description |
Y+L amino acid transporter 2|amino acid permease|cationic amino acid transporter, y+ system|solute carrier family 7 (cationic amino acid transporter, y+ system), member 6|solute carrier family 7 member 6|y(+)L-type amino acid transporter 2|y+LAT2
|
| Swissprots |
Q92536 Q7L1N3 Q68DS4
|
| Accessions |
EAW83219 EAW83220 Q92536 AK310602 AK310866 AK311610 BC028216 AAH28216 BC113100 AAI13101 BP242589 CR749291 CAH18146 CR749475 CAH18305 D87432 BAA13376 DB107640 DQ891023 ABM81949 DQ894203 ABM85129 R48943 XM_011523433 XP_011521735 XM_011523434 XP_011521736 XM_011523435 XP_011521737 XM_011523436 XP_011521738 XM_011523437 XP_011521739 XM_011523438 XP_011521740 XM_011523439 XP_011521741 XR_243433 NM_001076785 NP_001070253 NM_003983 NP_003974
|
| Function |
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells. {ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974}.
|
| Subcellular Location |
Basolateral cell membrane {ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209}; Multi- pass membrane protein {ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209}.
|
| Tissue Specificity |
Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines. {ECO:0000269|PubMed:11078698, ECO:0000269|PubMed:11742806, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401}.
|