| Gene Symbol |
ITGAL
|
| Entrez Gene |
3683
|
| Alt Symbol |
CD11A, LFA-1, LFA1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
|
| Other Description |
CD11 antigen-like family member A|LFA-1 alpha|LFA-1A|antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide|integrin alpha-L|integrin gene promoter|leukocyte adhesion glycoprotein LFA-1 alpha chain|leukocyte function-associated molecule 1 alpha chain|lymphocyte function-associated antigen 1
|
| Swissprots |
Q9UBC8 O43746 Q96HB1 Q45H73 P20701
|
| Accessions |
AAA16474 AAC31672 AAZ38713 CAA80461 EAW52243 EAW52244 EAW52245 P20701 AK298674 BAG60839 AK303190 BAG64283 AK314246 BAG36913 BC008777 AAH08777 CA430398 DC324373 Y00796 CAA68747 XM_005255313 XP_005255370 XM_006721044 XP_006721107 XM_011545849 XP_011544151 XR_950794 NM_001114380 NP_001107852 NM_002209 NP_002200
|
| Function |
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Leukocytes.
|
| Top Pathways |
Malaria, Rap1 signaling pathway, Epstein-Barr virus infection, HTLV-I infection, Rheumatoid arthritis
|
![Western Blot: CD11a Overexpression Lysate (Adult Normal) [NBL1-12068] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CD11a.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7575_CD11a%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12068-img0002.jpg)