Gene Symbol | ITGAL |
---|---|
Entrez Gene | 3683 |
Alt Symbol | CD11A, LFA-1, LFA1A |
Species | Human |
Gene Type | protein-coding |
Description | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
Other Description | CD11 antigen-like family member A|LFA-1 alpha|LFA-1A|antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide|integrin alpha-L|integrin gene promoter|leukocyte adhesion glycoprotein LFA-1 alpha chain|leukocyte function-associated molecule 1 alpha chain|lymphocyte function-associated antigen 1 |
Swissprots | Q9UBC8 O43746 Q96HB1 Q45H73 P20701 |
Accessions | AAA16474 AAC31672 AAZ38713 CAA80461 EAW52243 EAW52244 EAW52245 P20701 AK298674 BAG60839 AK303190 BAG64283 AK314246 BAG36913 BC008777 AAH08777 CA430398 DC324373 Y00796 CAA68747 XM_005255313 XP_005255370 XM_006721044 XP_006721107 XM_011545849 XP_011544151 XR_950794 NM_001114380 NP_001107852 NM_002209 NP_002200 |
Function | Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Leukocytes. |
Top Pathways | Malaria, Rap1 signaling pathway, Epstein-Barr virus infection, HTLV-I infection, Rheumatoid arthritis |
Integrin αL CRISPR/Cas9 KO Plasmid (h) - sc-402246 from Santa Cruz Biotechnology
|
||||||||
Integrin αL HDR Plasmid (h) - sc-402246-HDR from Santa Cruz Biotechnology
|
||||||||
Integrin αL Double Nickase Plasmid (h) - sc-402246-NIC from Santa Cruz Biotechnology
|
||||||||
Integrin αL Double Nickase Plasmid (h2) - sc-402246-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Integrin αL CRISPR Activation Plasmid (h) - sc-402246-ACT from Santa Cruz Biotechnology
|
||||||||
Integrin αL CRISPR Activation Plasmid (h2) - sc-402246-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Integrin αL Lentiviral Activation Particles (h) - sc-402246-LAC from Santa Cruz Biotechnology
|
||||||||
Integrin αL Lentiviral Activation Particles (h2) - sc-402246-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Integrin αL siRNA (h) - sc-35691 from Santa Cruz Biotechnology
|
||||||||
Integrin αL shRNA Plasmid (h) - sc-35691-SH from Santa Cruz Biotechnology
|
||||||||
Integrin αL shRNA (h) Lentiviral Particles - sc-35691-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU059771 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN10814 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10814 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR09639 from Sigma-Aldrich
|
||||||||
ITGAL siRNA (Human) - CRH2473 from Cohesion Biosciences
|
||||||||
Integrin alpha L/CD11a RNAi - H00003683-R01 from Novus Biologicals
|
||||||||
ITGAL - MBS8212791 from MyBioSource
|
||||||||
shRNA set against Human ITGAL (NM_002209.2) - SHH321293 from Creative biogene
|
||||||||
shRNA set against Human ITGAL(NM_002209.2) - SHL181686 from Creative biogene
|
||||||||
Human ITGAL siRNA - orb262975 from Biorbyt
|
||||||||
ITGAL shRNA Plasmid (Human) - CHH2473 from Cohesion Biosciences
|
||||||||
ITGAL miRNA 3'UTR clone - MiUTR1H-05029 from Creative biogene
|
||||||||
ITGAL miRNA 3'UTR clone - MiUTR3H-01350 from Creative biogene
|