| Gene Symbol |
SPON1
|
| Entrez Gene |
10418
|
| Alt Symbol |
VSGP/F-spondin, f-spondin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spondin 1, extracellular matrix protein
|
| Other Description |
spondin 1, (f-spondin) extracellular matrix protein|spondin-1|vascular smooth muscle cell growth-promoting factor
|
| Swissprots |
O94862 Q9HCB6 Q8WUR5 A8K6W5 Q8NCD7
|
| Accessions |
CAF86814 EAW68488 EAW68489 Q9HCB6 AB018305 BAA34482 AB051390 BAB18461 AI424944 AK001584 BAG50943 AK074803 BAC11217 AK291780 BAF84469 BC019825 AAH19825 BC041974 AAH41974 BC136513 AAI36514 BC136563 AAI36564 BM671036 BQ026865 DA965056 NM_006108 NP_006099
|
| Function |
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. {ECO:0000250}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Tissue Specificity |
Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen. {ECO:0000269|PubMed:11368520, ECO:0000269|PubMed:9872452}.
|
![Western Blot: Spondin-1 Overexpression Lysate (Adult Normal) [NBL1-16417] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Spondin-1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6265_Spondin-1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16417-img0002.jpg)