Gene Symbol | SPON1 |
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Entrez Gene | 10418 |
Alt Symbol | VSGP/F-spondin, f-spondin |
Species | Human |
Gene Type | protein-coding |
Description | spondin 1, extracellular matrix protein |
Other Description | spondin 1, (f-spondin) extracellular matrix protein|spondin-1|vascular smooth muscle cell growth-promoting factor |
Swissprots | O94862 Q9HCB6 Q8WUR5 A8K6W5 Q8NCD7 |
Accessions | CAF86814 EAW68488 EAW68489 Q9HCB6 AB018305 BAA34482 AB051390 BAB18461 AI424944 AK001584 BAG50943 AK074803 BAC11217 AK291780 BAF84469 BC019825 AAH19825 BC041974 AAH41974 BC136513 AAI36514 BC136563 AAI36564 BM671036 BQ026865 DA965056 NM_006108 NP_006099 |
Function | Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell. {ECO:0000250}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
Tissue Specificity | Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen. {ECO:0000269|PubMed:11368520, ECO:0000269|PubMed:9872452}. |
F-Spondin CRISPR/Cas9 KO Plasmid (h) - sc-404101 from Santa Cruz Biotechnology
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F-Spondin HDR Plasmid (h) - sc-404101-HDR from Santa Cruz Biotechnology
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F-Spondin Double Nickase Plasmid (h) - sc-404101-NIC from Santa Cruz Biotechnology
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F-Spondin Double Nickase Plasmid (h2) - sc-404101-NIC-2 from Santa Cruz Biotechnology
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F-Spondin CRISPR Activation Plasmid (h) - sc-404101-ACT from Santa Cruz Biotechnology
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F-Spondin CRISPR Activation Plasmid (h2) - sc-404101-ACT-2 from Santa Cruz Biotechnology
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F-Spondin Lentiviral Activation Particles (h) - sc-404101-LAC from Santa Cruz Biotechnology
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F-Spondin Lentiviral Activation Particles (h2) - sc-404101-LAC-2 from Santa Cruz Biotechnology
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F-Spondin siRNA (h) - sc-60613 from Santa Cruz Biotechnology
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F-Spondin shRNA Plasmid (h) - sc-60613-SH from Santa Cruz Biotechnology
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F-Spondin shRNA (h) Lentiviral Particles - sc-60613-V from Santa Cruz Biotechnology
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F-Spondin/SPON1 RNAi - H00010418-R01 from Novus Biologicals
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MISSION® esiRNA - EHU024101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20505 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20505 from Sigma-Aldrich
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SPON1 siRNA (Human) - CRH7063 from Cohesion Biosciences
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SPON1 - MBS8219645 from MyBioSource
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F-Spondin CRISPR/Cas9 KO Plasmid (h2) - sc-404101-KO-2 from Santa Cruz Biotechnology
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F-Spondin HDR Plasmid (h2) - sc-404101-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Spon1 (NM_006108.3) - SHH417064 from Creative biogene
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Human SPON1 siRNA - orb267565 from Biorbyt
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SPON1 shRNA Plasmid (Human) - CHH7063 from Cohesion Biosciences
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