| Gene Symbol |
OGDH
|
| Entrez Gene |
4967
|
| Alt Symbol |
AKGDH, E1k, OGDC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
|
| Other Description |
2-oxoglutarate dehydrogenase complex component E1|2-oxoglutarate dehydrogenase, mitochondrial|OGDC-E1|oxoglutarate decarboxylase|oxoglutarate dehydrogenase (succinyl-transferring)
|
| Swissprots |
Q9UDX0 D3DVL0 Q96DD3 E9PBM1 Q02218 B4E2U9
|
| Accessions |
AAQ96884 AAQ96885 BAA06836 EAW61086 EAW61087 EAW61088 EAW61089 Q02218 AI244565 AK293871 BAG57261 AK294951 BAG58026 AK296400 BAG59067 AK302805 BAG64007 AK304439 BAG65261 AK304690 BAG65461 AK314179 AU140451 BC004964 AAH04964 BC009580 AAH09580 BC014617 AAH14617 BC128549 AAI28550 BC128550 AAI28551 BM998792 BU682361 D10523 BAA01393 DC401267 DQ891880 ABM82806 DQ925673 ABL59900 DQ925674 ABL59901 EU176648 ABW03449 XM_005249759 XP_005249816 XM_005249761 XP_005249818 XM_011515408 XP_011513710 NM_001003941 NP_001003941 NM_001165036 NP_001158508 NM_002541 NP_002532
|
| Function |
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
|
| Subcellular Location |
Mitochondrion matrix.
|
| Top Pathways |
Citrate cycle (TCA cycle), Lysine degradation, Tryptophan metabolism, Carbon metabolism
|