Rptor

Gene Symbol Rptor
Entrez Gene 74370
Alt Symbol 4932417H02Rik, Rap, Raptor, mKIAA1303
Species Mouse
Gene Type protein-coding
Description regulatory associated protein of MTOR, complex 1
Other Description p150 target of rapamycin (TOR)-scaffold protein|regulatory-associated protein of mTOR
Swissprots Q8K4Q0 Q8C9W9 Q8CBY4 Q8CDY8 Q9D4H3
Accessions EDL34713 EDL34714 EDL34715 Q8K4Q0 AB082952 BAC06491 AK016530 BAB30288 AK029341 AK034306 BAC28669 AK034557 BAC28753 AK034733 AK040288 BAC30561 AK046898 AK081250 AK087217 AK129326 BAC98136 AK137878 AK144082 AK161011 AK172276 BC023733 BC052202 BC059877 BC060140 BC118971 AAI18972 BC148309 AAI48310 BC167200 AAI67200 XM_006534361 XP_006534424 XM_006534362 XP_006534425 XM_006534363 XP_006534426 XM_006534364 XP_006534427 XM_011249285 XP_011247587 XM_011249286 XP_011247588 NM_001306081 NP_001293010 NM_028898 NP_083174
Function Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylati
Subcellular Location Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Note=Targeting to lysosomes depends on amino acid availability (By similarity). During oxidative stress, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased. {ECO:0000250}.
Top Pathways Insulin signaling pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer, AMPK signaling pathway, mTOR signaling pathway

Anti-Raptor antibody - ab25975 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Raptor antibody (ab25975) at 2 µg/mlLane 2 : Anti-Raptor antibody (ab25975) at 4 µg/mlLane 1 : L1210 cell lysate.Lane 2 : L1210 cell lysate.

RPTOR Antibody - NBP1-76613 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RPTOR Antibody [NBP1-76613] - L1210 cell lysate with Raptor antibody at (A) 2 and (B) 4 ug/ml.

Anti-Raptor (ab1) antibody produced in rabbit - PRS3489 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunocytochemistry</B><BR/>Anti-Raptor: <B>Cat. No. PRS3489</B> Immunocytochemistry of Raptor in L1210 cells with Raptor antibody at 10 μg/mL.

Raptor antibody - orb74608 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of L1210 cell lysate at (A) 2 and (B) 4 ug/mL using Raptor antibody

RAPTOR (C-term) antibody - AP30708PU-N from Acris Antibodies

Prices $340.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry of Raptor in L1210 cells with AP30708PU-N at 10 μg/ml.

RAPTOR antibody - PAB13417 from Acris Antibodies

Prices $420.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry of Rptor in L1210 cells with Rptor polyclonal antibody ( Cat # PAB13417 ) at 10 µg/ml.

Rabbit Anti-Human RAPTOR - DS-PB-01723 from RayBiotech

Host Rabbit

Raptor Antibody - 3489 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Raptor in L1210 cell lysate with Raptor antibody at (A) 2 and (B) 4 μg/mL.

Raptor Antibody - 3491 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of RAPTOR expression in Jurkat cell lysate with RAPTOR antibody at (A) 1 and (B) 2 μg/ml.

Raptor Antibody - 3493 from ProSci

Prices $79.00, $325.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Raptor in L1210 cell lysate with Raptor (IN) antibody at (A) 2 and (B) 4 μg/mL.

Raptor Antibody - 253522 from ABBIOTEC

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Raptor Antibody - 24302 from Signalway Antibody

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of Raptor in L1210 cell lysate with Raptor antibody at (A) 2 and (B) 4 ug/mL.

Anti-RPTOR (C-terminal) polyclonal antibody - DPAB-L20982 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Raptor Polyclonal Antibody - PA5-20124 from Thermo Fisher Scientific

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of L1210 cell lysate using a Raptor polyclonal antibody (Product # PA5-20124) at (A) 2 and (B) 4 ug/mL.

Raptor, Polyclonal Antibody - MBS151576 from MyBioSource

Prices $140.00, $355.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Raptor, Polyclonal Antibody - MBS150840 from MyBioSource

Prices $140.00, $355.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Raptor, Polyclonal Antibody - MBS150268 from MyBioSource

Prices $140.00, $355.00
Sizes 20 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Raptor Antibody - 600-401-DW4 from Rockland Immunochemicals Inc

Prices $319.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Raptor, Polyclonal Antibody - MBS9414804 from MyBioSource

Prices $320.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Raptor (C-Terminus) antibody - pab80224 from Covalab

Host Rabbit
Clonality Polyclonal

Raptor-Antibody - ASC10311 from Abgent, a WuXi AppTec company

Prices $320.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Raptor in L1210 cell lysate with Raptor (IN) antibody at (A) 2 and (B) 4 µg/mL.

Raptor-Antibody - ASC10310 from Abgent, a WuXi AppTec company

Prices $320.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Raptor in L1210 cell lysate with Raptor antibody at (A) 2 and (B) 4 µg/mL.

Raptor-Antibody - ASC10309 from Abgent, a WuXi AppTec company

Prices $320.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Raptor in L1210 cell lysate with Raptor antibody at (A) 2 and (B) 4 µg/mL.

RAPTOR (C-term) antibody - TA306211 from Acris Antibodies

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of Raptor in L1210 cell lysate with Raptor antibody at (A) 2 and (B) 4 ug/ml.

Anti-Raptor Antibody A01463 - A01463 from Boster Bio

Prices $245.00
Sizes 1
Host Rabbit
Clonality Polyclonal
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