| Gene Symbol |
Rptor
|
| Entrez Gene |
74370
|
| Alt Symbol |
4932417H02Rik, Rap, Raptor, mKIAA1303
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
regulatory associated protein of MTOR, complex 1
|
| Other Description |
p150 target of rapamycin (TOR)-scaffold protein|regulatory-associated protein of mTOR
|
| Swissprots |
Q8K4Q0 Q8C9W9 Q8CBY4 Q8CDY8 Q9D4H3
|
| Accessions |
EDL34713 EDL34714 EDL34715 Q8K4Q0 AB082952 BAC06491 AK016530 BAB30288 AK029341 AK034306 BAC28669 AK034557 BAC28753 AK034733 AK040288 BAC30561 AK046898 AK081250 AK087217 AK129326 BAC98136 AK137878 AK144082 AK161011 AK172276 BC023733 BC052202 BC059877 BC060140 BC118971 AAI18972 BC148309 AAI48310 BC167200 AAI67200 XM_006534361 XP_006534424 XM_006534362 XP_006534425 XM_006534363 XP_006534426 XM_006534364 XP_006534427 XM_011249285 XP_011247587 XM_011249286 XP_011247588 NM_001306081 NP_001293010 NM_028898 NP_083174
|
| Function |
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylati
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Note=Targeting to lysosomes depends on amino acid availability (By similarity). During oxidative stress, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased. {ECO:0000250}.
|
| Top Pathways |
Insulin signaling pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer, AMPK signaling pathway, mTOR signaling pathway
|