| Gene Symbol |
HAMP
|
| Entrez Gene |
57817
|
| Alt Symbol |
HEPC, HFE2B, LEAP1, PLTR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hepcidin antimicrobial peptide
|
| Other Description |
hepcidin|liver-expressed antimicrobial peptide 1|putative liver tumor regressor
|
| Swissprots |
P81172 Q9BY68 Q1HE14
|
| Accessions |
ABF47098 CAG29368 CAR82669 CAR82670 CAR82671 CAR82672 CAR82673 CAR82674 CAR82675 CAR82676 CAR82677 CAR82678 CAR82679 CAR82680 CAR82681 CAR82682 CAR82683 CAR82684 CAR82685 CAR82686 CAR82687 CAR82688 CAR82689 CAR82690 CAR82691 CAR82692 CAR82693 CAR82694 CAR82695 CAR82696 CAR82697 CAR82698 CAR82699 CAR82700 CAR82701 CAR82702 P81172 AF131292 AAK14912 AF147355 AF309489 AAG23966 AJ277280 CAC09419 AK096110 AY358669 AAQ89032 BC020612 AAH20612 NM_021175 NP_066998
|
| Function |
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). {ECO:0000269|PubMed:22306005}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine. {ECO:0000269|PubMed:11034317}.
|