| Gene Symbol | TCTN1 |
|---|---|
| Entrez Gene | 79600 |
| Alt Symbol | JBTS13, TECT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tectonic family member 1 |
| Other Description | tectonic-1 |
| Swissprots | Q8NAE9 Q9H798 Q49A60 Q2MV58 Q96N72 Q6P5X1 Q6UXW2 A8MX11 |
| Accessions | EAW97929 EAW97930 EAW97931 EAW97932 Q2MV58 AK024780 BAB15000 AK055891 BAB71036 AK092775 BAC03973 AK128417 AK295514 BAG58431 AK301732 BAH13543 AY358184 AAQ88551 BC030993 AAH30993 BC033811 AAH33811 BC040113 AAH40113 BC044885 BC062611 AAH62611 BP275624 CA419765 DN997186 DQ278868 ABB90560 XM_005253934 XP_005253991 XM_005253935 XP_005253992 XM_005253936 XP_005253993 XM_006719594 XP_006719657 XM_006719595 XP_006719658 XM_006719596 XP_006719659 XM_006719597 XP_006719660 XM_006719598 XP_006719661 XM_006719599 XP_006719662 XM_006719600 XP_006719663 XM_011538733 XP_011537035 XM_011538734 XP_011537036 XM_011538735 XP_011537037 XM_011538736 XP_011537038 XM_011538737 XP_011537039 XM_011538738 XP_011537040 XM_011538739 XP_011537041 XR_243021 XR_243022 XR_429116 XR_944717 NM_001082537 NP_001076006 NM_001082538 NP_001076007 NM_001173975 NP_001167446 NM_001173976 NP_001167447 NM_024549 NP_078825 |
| Function | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Secreted {ECO:0000305}. Note=Despite the presence of a signal sequence, the full length protein might not be secreted. Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}. |
Tect1 CRISPR/Cas9 KO Plasmid (h) - sc-413181 from Santa Cruz Biotechnology
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Tect1 HDR Plasmid (h) - sc-413181-HDR from Santa Cruz Biotechnology
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Tect1 Double Nickase Plasmid (h) - sc-413181-NIC from Santa Cruz Biotechnology
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Tect1 Double Nickase Plasmid (h2) - sc-413181-NIC-2 from Santa Cruz Biotechnology
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Tect1 CRISPR Activation Plasmid (h) - sc-413181-ACT from Santa Cruz Biotechnology
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Tect1 CRISPR Activation Plasmid (h2) - sc-413181-ACT-2 from Santa Cruz Biotechnology
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Tect1 Lentiviral Activation Particles (h) - sc-413181-LAC from Santa Cruz Biotechnology
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Tect1 Lentiviral Activation Particles (h2) - sc-413181-LAC-2 from Santa Cruz Biotechnology
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Tect1 siRNA (h) - sc-96235 from Santa Cruz Biotechnology
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Tect1 shRNA Plasmid (h) - sc-96235-SH from Santa Cruz Biotechnology
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Tect1 shRNA (h) Lentiviral Particles - sc-96235-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU102341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21175 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21175 from Sigma-Aldrich
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TCTN1 siRNA (Human) - CRJ2418 from Cohesion Biosciences
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TCTN1 - MBS8218217 from MyBioSource
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shRNA set against Human TCTN1 (NM_024549.5) - SHH425214 from Creative biogene
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Human TCTN1 siRNA - orb272919 from Biorbyt
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TCTN1 shRNA Plasmid (Human) - CHJ2418 from Cohesion Biosciences
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TCTN1 miRNA 3'UTR clone - MiUTR3H-10855 from Creative biogene
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TCTN1 miRNA 3'UTR clone - MiUTR3H-10856 from Creative biogene
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TCTN1 miRNA 3'UTR clone - MiUTR3H-10857 from Creative biogene
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