CLEC4M
| Gene Symbol | CLEC4M |
|---|---|
| Entrez Gene | 10332 |
| Alt Symbol | CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN |
| Species | Human |
| Gene Type | protein-coding |
| Description | C-type lectin domain family 4, member M |
| Other Description | C-type lectin domain family 4 member M|CD209 antigen-like protein 1|CD299 antigen|DC-SIGN-related protein|dendritic cell-specific ICAM-3-grabbing non-integrin 2|liver/lymph node-specific ICAM-3 grabbing non-integrin|liver/lymph node-specific ICAM-3-grabbing non-integrin|mannose binding C-type lectin DC-SIGNR |
| Swissprots | Q96QP6 A6NKI4 Q9Y2A8 Q9H2X3 Q9BXS3 Q96QP5 Q69F40 Q9H2Q9 Q969M4 Q96QP3 Q96QP4 A8K8B3 Q9H8F0 |
| Accessions | AAG13815 EAW68983 EAW68984 EAW68985 EAW68986 EAW68987 EAW68988 EAW68989 EAW68990 Q9H2X3 AA431250 AB015629 BAA76496 AF245219 AAG13848 AF290887 AAK20998 AK023750 BAB14667 AK292278 BAF84967 AK298084 BAG60371 AK304499 BAG65307 AK314704 AY042234 AAK91859 AY042235 AAK91860 AY042236 AAK91861 AY042237 AAK91862 AY042238 AAK91863 AY042239 AAK91864 AY042240 AAK91865 AY343913 AAR04559 BC038851 AAH38851 BC110614 AAI10615 BQ008265 BX102225 DB030283 DB048428 DQ893779 ABM84705 XM_006722611 XP_006722674 XM_006722612 XP_006722675 XM_006722613 XP_006722676 XM_006722614 XP_006722677 XM_006722615 XP_006722678 XR_430125 XR_936147 NM_001144904 NP_001138376 NM_001144905 NP_001138377 NM_001144906 NP_001138378 NM_001144907 NP_001138379 NM_001144908 NP_001138380 NM_001144909 NP_001138381 NM_001144910 NP_001138382 NM_001144911 NP_001138383 NM_014257 NP_055072 NR_026707 NR_026708 NR_026709 NM_214675 NM_214676 |
| Function | Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus. {ECO:0000269|PubMed:11226297, ECO:0000269|PubMed:11257134}. |
| Subcellular Location | Isoform 10: Secreted {ECO:0000305}. |
| Tissue Specificity | Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells. {ECO:0000269|PubMed:11226297, ECO:0000269|PubMed:11257134, ECO:0000269|PubMed:15496474}. |
| Top Pathways | Phagosome, Measles, Tuberculosis |
DC-SIGNR CRISPR/Cas9 KO Plasmid (h) - sc-404217 from Santa Cruz Biotechnology
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DC-SIGNR HDR Plasmid (h) - sc-404217-HDR from Santa Cruz Biotechnology
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DC-SIGNR Double Nickase Plasmid (h) - sc-404217-NIC from Santa Cruz Biotechnology
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DC-SIGNR Double Nickase Plasmid (h2) - sc-404217-NIC-2 from Santa Cruz Biotechnology
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DC-SIGNR CRISPR Activation Plasmid (h) - sc-404217-ACT from Santa Cruz Biotechnology
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DC-SIGNR CRISPR Activation Plasmid (h2) - sc-404217-ACT-2 from Santa Cruz Biotechnology
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DC-SIGNR Lentiviral Activation Particles (h) - sc-404217-LAC from Santa Cruz Biotechnology
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DC-SIGNR Lentiviral Activation Particles (h2) - sc-404217-LAC-2 from Santa Cruz Biotechnology
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DC-SIGNR siRNA (h) - sc-42859 from Santa Cruz Biotechnology
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DC-SIGNR shRNA Plasmid (h) - sc-42859-SH from Santa Cruz Biotechnology
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DC-SIGNR shRNA (h) Lentiviral Particles - sc-42859-V from Santa Cruz Biotechnology
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DC-SIGNR/CD299/CLEC4M RNAi - H00010332-R11 from Novus Biologicals
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DC-SIGNR/CD299/CLEC4M RNAi - H00010332-R08 from Novus Biologicals
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DC-SIGNR/CD299/CLEC4M RNAi - H00010332-R10 from Novus Biologicals
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DC-SIGNR/CD299/CLEC4M RNAi - H00010332-R09 from Novus Biologicals
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MISSION® esiRNA - EHU122831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6221 from Sigma-Aldrich
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CLEC4M siRNA (Human) - CRH7005 from Cohesion Biosciences
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DC-SIGNR/CD299/CLEC4M RNAi - H00010332-R07 from Novus Biologicals
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DC-SIGNR/CD299/CLEC4M RNAi - H00010332-R12 from Novus Biologicals
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CLEC4M - MBS8207211 from MyBioSource
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shRNA set against Human CLEC4M (NM_014257.4) - SHH265201 from Creative biogene
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Human CLEC4M siRNA - orb267507 from Biorbyt
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CLEC4M shRNA Plasmid (Human) - CHH7005 from Cohesion Biosciences
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