CLEC4M

Gene Symbol CLEC4M
Entrez Gene 10332
Alt Symbol CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN
Species Human
Gene Type protein-coding
Description C-type lectin domain family 4, member M
Other Description C-type lectin domain family 4 member M|CD209 antigen-like protein 1|CD299 antigen|DC-SIGN-related protein|dendritic cell-specific ICAM-3-grabbing non-integrin 2|liver/lymph node-specific ICAM-3 grabbing non-integrin|liver/lymph node-specific ICAM-3-grabbing non-integrin|mannose binding C-type lectin DC-SIGNR
Swissprots Q96QP6 A6NKI4 Q9Y2A8 Q9H2X3 Q9BXS3 Q96QP5 Q69F40 Q9H2Q9 Q969M4 Q96QP3 Q96QP4 A8K8B3 Q9H8F0
Accessions AAG13815 EAW68983 EAW68984 EAW68985 EAW68986 EAW68987 EAW68988 EAW68989 EAW68990 Q9H2X3 AA431250 AB015629 BAA76496 AF245219 AAG13848 AF290887 AAK20998 AK023750 BAB14667 AK292278 BAF84967 AK298084 BAG60371 AK304499 BAG65307 AK314704 AY042234 AAK91859 AY042235 AAK91860 AY042236 AAK91861 AY042237 AAK91862 AY042238 AAK91863 AY042239 AAK91864 AY042240 AAK91865 AY343913 AAR04559 BC038851 AAH38851 BC110614 AAI10615 BQ008265 BX102225 DB030283 DB048428 DQ893779 ABM84705 XM_006722611 XP_006722674 XM_006722612 XP_006722675 XM_006722613 XP_006722676 XM_006722614 XP_006722677 XM_006722615 XP_006722678 XR_430125 XR_936147 NM_001144904 NP_001138376 NM_001144905 NP_001138377 NM_001144906 NP_001138378 NM_001144907 NP_001138379 NM_001144908 NP_001138380 NM_001144909 NP_001138381 NM_001144910 NP_001138382 NM_001144911 NP_001138383 NM_014257 NP_055072 NR_026707 NR_026708 NR_026709 NM_214675 NM_214676
Function Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus. {ECO:0000269|PubMed:11226297, ECO:0000269|PubMed:11257134}.
Subcellular Location Isoform 10: Secreted {ECO:0000305}.
Tissue Specificity Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells. {ECO:0000269|PubMed:11226297, ECO:0000269|PubMed:11257134, ECO:0000269|PubMed:15496474}.
Top Pathways Phagosome, Measles, Tuberculosis

DC-SIGNR (F-2) - sc-390788 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DC-SIGNR (F-2): sc-390788. Western blot analysis of DC-SIGNR expression in HeLa whole cell lysate.

DC-SIGNR (G-8) - sc-393435 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DC-SIGNR (G-8): sc-393435. Western blot analysis of DC-SIGNR expression in non-transfected: sc-117752 (A) and human DC-SIGNR transfected: sc-115461 (B) 293T whole cell lysates.

DC-SIGN/DC-SIGNR (14E3G7) - sc-53965 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DC-SIGN/DC-SIGNR (14E3G7): sc-53965. Western blot analysis of DC-SIGNR expression in non-transfected: sc-117752 (A) and human DC-SIGNR transfected: sc-115461 (B) 293T whole cell lysates.

DC-SIGNR (C-10) - sc-271086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DC-SIGNR (C-10): sc-271086. Western blot analysis of DC-SIGN expression in non-transfected: sc-117752 (A) and human DC-SIGN transfected: sc-115461 (B) 293T whole cell lysates.

DC-SIGNR (H-2) - sc-271381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DC-SIGNR (H-2): sc-271381. Western blot analysis of DC-SIGNR expression in non-transfected: sc-117752 (A) and human DC-SIGNR transfected: sc-115461 (B) 293T whole cell lysates.

DC-SIGNR (C-17) - sc-17261 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DC-SIGNR (C-17): sc-17261. Western blot analysis of DC-SIGNR expression in non-transfected: sc-117752 (A) and human DC-SIGNR transfected: sc-115461 (B) 293T whole cell lysates.

DC-SIGNR (N-17) - sc-17259 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DC-SIGNR (N-17): sc-17259. Western blot analysis of DC-SIGNR expression in non-transfected: sc-117752 (A) and human DC-SIGNR transfected: sc-115461 (B) 293T whole cell lysates.

DC-SIGN/DC-SIGNR (19F7) - sc-53966 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DC-SIGN/DC-SIGNR(19F7): sc-53966. Western blot analysis of DC-SIGN expression in non-transfected: sc-117752 (A) and human DC-SIGN transfected: sc-115461 (B) 293T whole cell lysates.

Anti-CD299 antibody - ab58603 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CD299 antibody (ab58603) at 1.25 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-CD299 antibody - ab83201 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CD299 antibody (ab83201) at 1 µg/ml + fetal muscle lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-CD299 antibody - ab102060 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CD299 antibody (ab102060) at 1 µg/ml + Human fetal kidney lysate at 10 µg

Anti-CD299 antibody - ab107946 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CD299 antibody (ab107946) at 1 µg/ml + MCF7 Cell Lysate at 10 µg

Anti-CD299 antibody [EPR11211] - ab169783 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11211
All lanes : Anti-CD299 antibody [EPR11211] (ab169783) at 1/1000 dilutionLane 1 : Human fetal kidney lysateLane 2 : Human fetal liver lysateLane 3 : Human placenta lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-CD299 antibody [MM0241- 2U25] - ab89183 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0241- 2U25

Anti-CLEC4M / L-SIGN / CD299 Antibody (N-Terminus) - LS-C101964 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CLEC4M / CD299 antibody LS-C101964 Western blot of Fetal Muscle lysate.

Anti-CLEC4M / L-SIGN / CD299 Antibody (aa143-192) - LS-C117165 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CLEC4M / CD299 antibody LS-C117165 Western blot of MCF7 cell lysate.

Anti-CLEC4M / L-SIGN / CD299 Antibody (aa51-100) - LS-C31891 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CLEC4M / CD299 antibody LS-C31891 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-CLEC4M / L-SIGN / CD299 Antibody (aa242-399) - LS-C293567 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CLEC4M / L-SIGN / CD299.

Anti-CLEC4M / L-SIGN / CD299 Antibody (aa323-372) IHC-plus™ - LS-B11484 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CLEC4M / L-SIGN / CD299 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11484 concentration 10 ug/ml.

Anti-CLEC4M / L-SIGN / CD299 Antibody (aa285-394) - LS-C306989 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

DC-SIGN+DC-SIGNR Antibody (120612) - MAB1621 from Novus Biologicals

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Mouse
Clonality Monoclonal
Clone 120612
Human DC‑SIGN and DC‑SIGNR transfected 3T3 mouse embryonic fibroblast cell line were stained with Mouse Anti-Human DC‑SIGN+DC‑SIGNR Monoclonal Antibody (Catalog # MAB1621, filled histo­grams) or isotype control antibody (Catalog # MAB003, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG F(ab')2 Secondary Antibody (Catalog # F0102B).

DC-SIGNR/CD299/CLEC4M Antibody - NBP1-59182 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DC-SIGNR/CD299/CLEC4M Antibody [NBP1-59182] - HepG2 cell lysate, Antibody Titration: 1.25ug/ml

DC-SIGNR/CD299/CLEC4M Antibody (128G8) - DDX0201P-100 from Novus Biologicals

Prices $249.00, $329.00
Sizes 50 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 128G8
Immunohistochemistry: DC-SIGNR/CD299/CLEC4M Antibody (128G8) [DDX0201P-100] - Deep layer: lymphatic vessels

DC-SIGNR/CD299/CLEC4M Antibody (118A8.05) - DDX0200P-100 from Novus Biologicals

Prices $249.00, $329.00
Sizes 50 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 118A8.05
Immunohistochemistry: DC-SIGNR/CD299/CLEC4M Antibody (118A8.05) [DDX0200P-100] - Analysis of human skin frozen section with clone 118A8 (DX0200)

DC-SIGNR/CD299/CLEC4M Antibody - NBP1-59183 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
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