| Gene Symbol |
Parl
|
| Entrez Gene |
381038
|
| Alt Symbol |
D16Ertd607e, PRO2207, PSARL1, PSENIP2, Psarl
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
presenilin associated, rhomboid-like
|
| Other Description |
mitochondrial intramembrane-cleaving protease PARL|presenilins-associated rhomboid-like protein, mitochondrial
|
| Swissprots |
Q641T5 Q5XJY4 Q3U9T5
|
| Accessions |
EDK97562 Q5XJY4 AK039142 AK150980 AK151652 BAE30581 AK179606 AK181973 AK205766 AK207495 AK207637 AK209149 AK212159 AK216516 AK218894 BC083153 AAH83153 XR_384575 NM_001005767 NP_001005767
|
| Function |
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:16839884}; Multi-pass membrane protein {ECO:0000269|PubMed:16839884}.
|