Gene Symbol | Parl |
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Entrez Gene | 381038 |
Alt Symbol | D16Ertd607e, PRO2207, PSARL1, PSENIP2, Psarl |
Species | Mouse |
Gene Type | protein-coding |
Description | presenilin associated, rhomboid-like |
Other Description | mitochondrial intramembrane-cleaving protease PARL|presenilins-associated rhomboid-like protein, mitochondrial |
Swissprots | Q641T5 Q5XJY4 Q3U9T5 |
Accessions | EDK97562 Q5XJY4 AK039142 AK150980 AK151652 BAE30581 AK179606 AK181973 AK205766 AK207495 AK207637 AK209149 AK212159 AK216516 AK218894 BC083153 AAH83153 XR_384575 NM_001005767 NP_001005767 |
Function | Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:16839884}; Multi-pass membrane protein {ECO:0000269|PubMed:16839884}. |
PARL CRISPR/Cas9 KO Plasmid (m) - sc-436232 from Santa Cruz Biotechnology
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PARL HDR Plasmid (m) - sc-436232-HDR from Santa Cruz Biotechnology
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PARL Double Nickase Plasmid (m) - sc-436232-NIC from Santa Cruz Biotechnology
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PARL Double Nickase Plasmid (m2) - sc-436232-NIC-2 from Santa Cruz Biotechnology
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PARL CRISPR Activation Plasmid (m) - sc-436232-ACT from Santa Cruz Biotechnology
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PARL CRISPR Activation Plasmid (m2) - sc-436232-ACT-2 from Santa Cruz Biotechnology
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PARL Lentiviral Activation Particles (m) - sc-436232-LAC from Santa Cruz Biotechnology
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PARL Lentiviral Activation Particles (m2) - sc-436232-LAC-2 from Santa Cruz Biotechnology
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PARL siRNA (m) - sc-61296 from Santa Cruz Biotechnology
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PARL shRNA Plasmid (m) - sc-61296-SH from Santa Cruz Biotechnology
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PARL shRNA (m) Lentiviral Particles - sc-61296-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU179171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38260 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38260 from Sigma-Aldrich
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PARL siRNA (Mouse) - CRN4818 from Cohesion Biosciences
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shRNA set against Mouse PARL (NM_001005767.4) - SHH370768 from Creative biogene
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shRNA set against Mouse Parl(NM_001005767.4) - SHR088216 from Creative biogene
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Mouse PARL siRNA - orb294293 from Biorbyt
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PARL shRNA Plasmid (Mouse) - CHN4818 from Cohesion Biosciences
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PARL miRNA 3'UTR clone - MiUTR1M-08906 from Creative biogene
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