Gene Symbol | LEFTY1 |
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Entrez Gene | 10637 |
Alt Symbol | LEFTB, LEFTYB |
Species | Human |
Gene Type | protein-coding |
Description | left-right determination factor 1 |
Other Description | left-right determination factor B|left-right determination, factor B|protein lefty-1|protein lefty-B |
Swissprots | B2R7U0 Q5TE94 Q53H67 O75610 |
Accessions | AAC33967 EAW69760 O75610 AF081512 AAD48144 AK129605 AK222714 BAD96434 AK309263 AK313115 BAG35937 AY358873 AAQ89232 BC027883 AAH27883 DQ896626 ABM87625 HQ628628 AER93378 NM_020997 NP_066277 |
Function | Required for left-right axis determination as a regulator of LEFTY2 and NODAL. |
Subcellular Location | Secreted. |
Top Pathways | TGF-beta signaling pathway |
Lefty-B CRISPR/Cas9 KO Plasmid (h) - sc-411497 from Santa Cruz Biotechnology
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Lefty-B HDR Plasmid (h) - sc-411497-HDR from Santa Cruz Biotechnology
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Lefty-B Double Nickase Plasmid (h) - sc-411497-NIC from Santa Cruz Biotechnology
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Lefty-B Double Nickase Plasmid (h2) - sc-411497-NIC-2 from Santa Cruz Biotechnology
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Lefty CRISPR Activation Plasmid (h) - sc-411497-ACT from Santa Cruz Biotechnology
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Lefty-B CRISPR Activation Plasmid (h2) - sc-411497-ACT-2 from Santa Cruz Biotechnology
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Lefty-B Lentiviral Activation Particles (h) - sc-411497-LAC from Santa Cruz Biotechnology
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Lefty-B Lentiviral Activation Particles (h2) - sc-411497-LAC-2 from Santa Cruz Biotechnology
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Lefty-B siRNA (h) - sc-39790 from Santa Cruz Biotechnology
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Lefty-B shRNA Plasmid (h) - sc-39790-SH from Santa Cruz Biotechnology
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Lefty-B shRNA (h) Lentiviral Particles - sc-39790-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU052371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11636 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11636 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04639 from Sigma-Aldrich
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LEFTY1 siRNA (Human) - CRH7248 from Cohesion Biosciences
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Lefty-B RNAi - H00010637-R01 from Novus Biologicals
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shRNA set against Human LEFTY1 (NM_020997.3) - SHH329467 from Creative biogene
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Human LEFTY1 siRNA - orb267750 from Biorbyt
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LEFTY1 shRNA Plasmid (Human) - CHH7248 from Cohesion Biosciences
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LEFTY1 miRNA 3'UTR clone - MiUTR3H-05577 from Creative biogene
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