SMAD4

Gene Symbol	SMAD4
Entrez Gene	4089
Alt Symbol	DPC4, JIP, MADH4, MYHRS
Species	Human
Gene Type	protein-coding
Description	SMAD family member 4
Other Description	MAD homolog 4|SMAD, mothers against DPP homolog 4|deleted in pancreatic carcinoma locus 4|deletion target in pancreatic carcinoma 4|mothers against decapentaplegic homolog 4|mothers against decapentaplegic, Drosophila, homolog of, 4
Swissprots	A8K405 Q13485
Accessions	AAC03051 AHA34184 AHA34185 AHA34186 BAB40977 EAW62985 EAW62986 EAW62987 Q13485 AK290770 BAF83459 AU120224 BC002379 AAH02379 BM701399 BX647129 DQ891840 ABM82766 DQ895028 ABM85954 U44378 AAA91041 NM_005359 NP_005350
Function	In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD
Subcellular Location	Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R- SMAD. PDPK1 prevents its nuclear translocation in response to TGF- beta.
Top Pathways	Wnt signaling pathway, Pancreatic cancer, HTLV-I infection, Colorectal cancer, Chronic myeloid leukemia

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Smad4 full length protein - ab81764 from Abcam Category Protein Source E. coli Species Human

Human Smad4 full length protein - ab84652 from Abcam Category Protein Source E. coli Species Human

Smad4 Recombinant Protein - H00004089-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

Smad4 Protein - NBC1-22616 from Novus Biologicals Category Protein Species Human

Smad4 Partial Recombinant Protein - H00004089-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

Smad4 Peptide - P1417 from Novus Biologicals Category Peptide Species Human

Phospho-SMAD4T277-Antibody-Blocking-peptide - BP3251a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

SMAD4-Antibody-C-term-Blocking-Peptide - BP7753b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMAD4-Antibody-T277-Blocking-Peptide - BP7753a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMAD4 blocking peptide - GTX89968-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

SMAD4 Protein (OPPA01949) - OPPA01949 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human Mothers Against Decapentaplegic Homolog 4 protein - orb81368 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli

Human SMAD4 R protein - orb163489 from Biorbyt Category Protein Prices $204.00, $451.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

SMAD4 Blocking Peptide - 33R-10772 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

Smad4 Blocking Peptide - 33R-10496 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

SMAD4 protein (His tag) - 80R-1096 from Fitzgerald Category Protein Prices $250.00 Sizes 100 µg Source E.coli

Human Smad4 Protein - abx068075 from Abbexa Category Protein Source E.coli Species Human

SMAD4 Blocking Peptide - abx062903 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey, Pig, Zebrafish

SMAD4 Peptide - AC21-0065-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SMAD4 (1-552, His-tag) - AR09143PU-N from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

SMAD4 (1-552, His-tag) - AR09143PU-S from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

SMAD4 - H00004089-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMAD4 - H00004089-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMAD4 - H00004089-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMAD4 - H00004089-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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