| Gene Symbol |
Enpp7
|
| Entrez Gene |
303729
|
| Alt Symbol |
E-NPP 7
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
ectonucleotide pyrophosphatase/phosphodiesterase 7
|
| Other Description |
E-NPP7|NPP-7|alk-SMase|alkaline sphingomyelin phosphodiesterase|ectonucleotide pyrophosphatase/phosphodiesterase family member 7|intestinal alkaline sphingomyelinase|sphingomyelinase, intestinal alkaline
|
| Swissprots |
Q5EZ72
|
| Accessions |
EDM06769 Q5EZ72 AY568760 AAU03450 NM_001012466 NP_001012484
|
| Function |
Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in the jejunum. {ECO:0000269|PubMed:15708357}.
|
| Top Pathways |
Sphingolipid metabolism
|