| Gene Symbol | Enpp7 |
|---|---|
| Entrez Gene | 303729 |
| Alt Symbol | E-NPP 7 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | ectonucleotide pyrophosphatase/phosphodiesterase 7 |
| Other Description | E-NPP7|NPP-7|alk-SMase|alkaline sphingomyelin phosphodiesterase|ectonucleotide pyrophosphatase/phosphodiesterase family member 7|intestinal alkaline sphingomyelinase|sphingomyelinase, intestinal alkaline |
| Swissprots | Q5EZ72 |
| Accessions | EDM06769 Q5EZ72 AY568760 AAU03450 NM_001012466 NP_001012484 |
| Function | Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex. {ECO:0000250}. |
| Tissue Specificity | Highly expressed in the jejunum. {ECO:0000269|PubMed:15708357}. |
| Top Pathways | Sphingolipid metabolism |
CompoZr® Knockout ZFN Kit - CKOZFN53502 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND53502 from Sigma-Aldrich
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ENPP7 siRNA (Rat) - CRR4882 from Cohesion Biosciences
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ENPP7 - MBS8234958 from MyBioSource
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shRNA set against Rat ENPP7 (NM_001012466.1) - SHH285993 from Creative biogene
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shRNA set against Rat Enpp7(NM_001012466.1) - SHH034319 from Creative biogene
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Rat ENPP7 siRNA - orb299731 from Biorbyt
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ENPP7 shRNA Plasmid (Rat) - CHR4882 from Cohesion Biosciences
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ENPP7 miRNA 3'UTR clone - MiUTR1R-01737 from Creative biogene
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