Gene Symbol | LMOD3 |
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Entrez Gene | 56203 |
Alt Symbol | NEM10 |
Species | Human |
Gene Type | protein-coding |
Description | leiomodin 3 (fetal) |
Other Description | leiomodin, fetal form|leiomodin-3 |
Swissprots | B4DT85 Q8IUK4 Q5JPG6 Q0VAK6 Q0JTT2 Q96LS4 |
Accessions | EAW65471 EAW65472 Q0VAK6 AI014510 AK057852 BAB71596 AK096900 AK300096 BAG61897 AL832033 AL832709 CAI46110 AM393202 CAL38080 BC017925 BC039202 AAH39202 BC121019 AAI21020 DA563370 NM_001304418 NP_001291347 NM_198271 NP_938012 |
Function | Essential for the organization of sarcomeric actin thin filaments in skeletal muscle (PubMed:25250574). Increases the rate of actin polymerization (PubMed:25250574). {ECO:0000269|PubMed:25250574}. |
Subcellular Location | Cytoplasm. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25250574}. Note=Highly expressed in nonstriated areas of developing myotubes, where it shows a granular cytoplasmic pattern. In sarcomeres, highly expressed in the M band region and, at lower levels, along actin thin filaments. Not detected in Z-disks. In sarcomeres, may be located near, but not at, actin thin filament pointed end. {ECO:0000269|PubMed:25250574}. |
Tissue Specificity | Expressed in cardiac and at higher levels in skeletal muscles (at protein level). {ECO:0000269|PubMed:25250574}. |
Leiomodin 3 CRISPR/Cas9 KO Plasmid (h) - sc-406871 from Santa Cruz Biotechnology
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Leiomodin 3 HDR Plasmid (h) - sc-406871-HDR from Santa Cruz Biotechnology
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Leiomodin 3 Double Nickase Plasmid (h) - sc-406871-NIC from Santa Cruz Biotechnology
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Leiomodin 3 Double Nickase Plasmid (h2) - sc-406871-NIC-2 from Santa Cruz Biotechnology
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Leiomodin 3 CRISPR Activation Plasmid (h) - sc-406871-ACT from Santa Cruz Biotechnology
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Leiomodin 3 CRISPR Activation Plasmid (h2) - sc-406871-ACT-2 from Santa Cruz Biotechnology
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Leiomodin 3 Lentiviral Activation Particles (h) - sc-406871-LAC from Santa Cruz Biotechnology
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Leiomodin 3 Lentiviral Activation Particles (h2) - sc-406871-LAC-2 from Santa Cruz Biotechnology
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Leiomodin 3 siRNA (h) - sc-77903 from Santa Cruz Biotechnology
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Leiomodin 3 shRNA Plasmid (h) - sc-77903-SH from Santa Cruz Biotechnology
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Leiomodin 3 shRNA (h) Lentiviral Particles - sc-77903-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU039841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11781 from Sigma-Aldrich
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LMOD3 siRNA (Human) - CRJ1107 from Cohesion Biosciences
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shRNA set against Human LMOD3 (NM_198271.3) - SHH331115 from Creative biogene
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LMOD3 shRNA Plasmid (Human) - CHJ1107 from Cohesion Biosciences
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