| Gene Symbol |
IPO9
|
| Entrez Gene |
55705
|
| Alt Symbol |
Imp9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
importin 9
|
| Other Description |
importin-9|ran-binding protein 9|ranBP9
|
| Swissprots |
B1ASV5 Q9NW01 Q96SU6 Q96P70 Q8NCG9 Q9ULM8 Q8N1Y1 Q9P0A8 Q8N3I2
|
| Accessions |
CDI44530 EAW91375 EAW91376 EAW91377 Q96P70 AB033018 BAA86506 AF070633 AF161391 AAF28951 AF410465 AAL01416 AK001264 BAA91588 AK027532 BAB55181 AK055940 AK074740 BAC11173 AK094276 AK124260 AL833476 AL834323 CAD38991 BC003604 AAH03604 BC156331 AAI56332 DA861528 DB232332 XM_011509730 XP_011508032 NM_018085 NP_060555
|
| Function |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), R
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|