ZC3HAV1

Gene Symbol ZC3HAV1
Entrez Gene 56829
Alt Symbol ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2
Species Human
Gene Type protein-coding
Description zinc finger CCCH-type, antiviral 1
Other Description ADP-ribosyltransferase diphtheria toxin-like 13|zinc finger CCCH domain-containing protein 2|zinc finger CCCH-type antiviral protein 1
Swissprots A4D1S4 Q9P0Y7 A4D1R2 Q8IW57 Q9H8R9 Q8TAJ3 Q7Z2W4 Q96N79
Accessions EAL24040 EAL24041 EAW83902 EAW83903 EAW83904 EAW83905 Q7Z2W4 AF138863 AAF61195 AK023350 BAB14537 AK055851 BAB71028 AK098308 AK292811 BAF85500 BC002935 AAH02935 BC025308 AAH25308 BC027462 AAH27462 BC033105 AAH33105 BC038809 BC040956 AAH40956 BX571742 CAE11868 BX647138 BX647974 XM_005250501 XP_005250558 XM_011516412 XP_011514714 NM_020119 NP_064504 NM_024625 NP_078901
Function Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a mor
Subcellular Location Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250}.

ZAP (E-19) - sc-244681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ZCCHV antibody - ab105357 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ZCCHV antibody (ab105357) at 1 µg/ml + HeLa cell lysate at 15 µg

Anti-ZCCHV antibody - ab154680 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ZCCHV antibody (ab154680) at 1/10000 dilution + A431 whole cell lysate at 30 µg

Anti-ZCCHV antibody - ab73369 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab73369 stained HeLa cells. The cells were 4% PFA fixed (10 min), permabilised in 0.1% PBS-Tween (20 min) and incubated with the antibody (ab73369, 1µg/ml) for 1h at room temperature. 1%BSA / 10% normal goat serum / 0.3M glycine was used to block non-specific protein-protein interactions. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red). DAPI was used to stain the cell nuclei (blue). This antibody also gave a positive IF result in 100$% methanol fixed (5 mins) HePG2 and MCF7 cells. However, this Fast-Track antibody is not yet fully characterised. This image represents inconclusive preliminary data.

Anti-ZCCHV antibody - ab72216 from Abcam

Prices $242.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ZCCHV antibody - C-terminal - ab175322 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ZCCHV antibody - C-terminal (ab175322) at 1000 µg + NCI-H460 cell lysate at 35 µg

Anti-PARP13 / ZC3HAV1 Antibody (C-Terminus, APC) - LS-C242909 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP13 / ZC3HAV1 Antibody (C-Terminus, AP) - LS-C242908 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP13 / ZC3HAV1 Antibody (C-Terminus, FITC) - LS-C242912 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP13 / ZC3HAV1 Antibody (C-Terminus, Biotin) - LS-C242911 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP13 / ZC3HAV1 Antibody (C-Terminus, PE) - LS-C242913 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP13 / ZC3HAV1 Antibody (C-Terminus, Azide-free, HRP) - LS-C247285 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP13 / ZC3HAV1 Antibody (C-Terminus) - LS-C326461 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARP13 / ZC3HAV1 Antibody (aa604-632) - LS-C160741 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ZC3HAV1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cervix carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PARP13 / ZC3HAV1 Antibody (C-Terminus) - LS-C115869 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry of ZC3HAV1 in HeLa cells with ZC3HAV1 antibody at 20 ug/ml.

ZCCHV Antibody - NBP2-20940 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ZCCHV Antibody [NBP2-20940] - Sample (30 ug of whole cell lysate) A: A431 7. 5% SDS PAGE gel, diluted at 1:10000.

ZCCHV Antibody - NBP1-92607 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ZCCHV Antibody [NBP1-92607] - Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & the Golgi apparatus.

ZC3HAV1L Antibody - NBP1-77184 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: ZC3HAV1L Antibody [NBP1-77184] - HeLa cell lysate with ZC3HAV1 antibody at 1ug/mL in (A) the absence and (B) the presence of blocking peptide.

ANTI-ZC3HAV1 (C-TERM) antibody produced in rabbit - SAB1303474 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>ZC3HAV1 (C-term): <B>Cat. No. SAB1303474</B>: ZC3HAV1 in Human breast carcinoma tissue with ZC3HAV1 antibody (C-term) at 5 μg/mL.

Anti-ZC3HAV1 antibody produced in rabbit - HPA047818 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ZC3HAV1: <B>Cat. No. HPA047818</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.

Anti-ZC3HAV1 antibody produced in rabbit - SAB2701457 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ZC3HAV1: <B>Cat. No. SAB2701457</B>: Immunohistochemical analysis of paraffin-embedded U87 xenograft, using ZC3HAV1 antibody at 1:500 dilution.

Anti-ZC3HAV1 antibody produced in rabbit - SAB3500521 from Sigma-Aldrich

Prices $346.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunocytochemistry</B><BR/>Anti-ZC3HAV1: <B>Cat. No. SAB3500521</B>: ZC3HAV1 in HeLa cells with ZC3HAV1 antibody at 20 μg/mL.

ZC3HAV1 Antibody - C-terminal region (OAAB03103) - OAAB03103 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

ZC3HAV1-Antibody-C-term - AP5695b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
ZC3HAV1 Antibody (C-term) (Cat. #AP5695b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the ZC3HAV1 antibody detected the ZC3HAV1 protein (arrow).

ZC3HAV1 antibody - orb75457 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of HeLa cell lysate at 1ug/mL in (A) the absence and (B) the presence of blocking peptide using ZC3HAV1 antibody
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