ZC3HAV1

Gene Symbol	ZC3HAV1
Entrez Gene	56829
Alt Symbol	ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2
Species	Human
Gene Type	protein-coding
Description	zinc finger CCCH-type, antiviral 1
Other Description	ADP-ribosyltransferase diphtheria toxin-like 13|zinc finger CCCH domain-containing protein 2|zinc finger CCCH-type antiviral protein 1
Swissprots	A4D1S4 Q9P0Y7 A4D1R2 Q8IW57 Q9H8R9 Q8TAJ3 Q7Z2W4 Q96N79
Accessions	EAL24040 EAL24041 EAW83902 EAW83903 EAW83904 EAW83905 Q7Z2W4 AF138863 AAF61195 AK023350 BAB14537 AK055851 BAB71028 AK098308 AK292811 BAF85500 BC002935 AAH02935 BC025308 AAH25308 BC027462 AAH27462 BC033105 AAH33105 BC038809 BC040956 AAH40956 BX571742 CAE11868 BX647138 BX647974 XM_005250501 XP_005250558 XM_011516412 XP_011514714 NM_020119 NP_064504 NM_024625 NP_078901
Function	Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a mor
Subcellular Location	Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ZCCHV full length protein - ab153427 from Abcam Category Protein Source Wheat germ Species Human

Human ZCCHV peptide - ab73367 from Abcam Category Peptide

Human ZCCHV peptide - ab73368 from Abcam Category Peptide

Human ZCCHV protein fragment - ab153428 from Abcam Category Protein Source Wheat germ Species Human

PARP13 / ZC3HAV1 Antibody Blocking Peptide - LS-E30961 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PARP13 / ZC3HAV1 Antibody Blocking Peptide - LS-E7936 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ZCCHV Protein - H00056829-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ZCCHV Protein - H00056829-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ZC3HAV1-Antibody-C-term-Blocking-peptide - BP5695b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ZC3HAV1 - H00056829-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

ZC3HAV1 - H00056829-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ZC3HAV1 - H00056829-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ZC3HAV1 control peptide - AP26229CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

ZC3HAV1 Peptide - 5839P from ProSci Category Peptide Species Human

ZC3HAV1 fusion protein - Ag10364 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ZC3HAV1, His-tagged - ZC3HAV1-3787H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Zinc finger CCCH-type antiviral protein 1(ZC3HAV1) ,partial - CSB-YP767190HU CSB-EP767190HU CSB-BP767190HU CSB-MP767190HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Zinc finger CCCH-type antiviral protein 1(ZC3HAV1) ,partial, Recombinant Protein - MBS1339394 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ZCCHV Recombinant Protein Antigen - NBP1-92607PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ZC3HAV1 Peptide, Human - M34GP17724H from Creative Peptides Category Peptide Source Synthetic. Species Human

ZCCHV Recombinant Protein Antigen - NBP2-56107PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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