Gene Symbol | PDE3A |
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Entrez Gene | 5139 |
Alt Symbol | CGI-PDE, CGI-PDE A, CGI-PDE-A |
Species | Human |
Gene Type | protein-coding |
Description | phosphodiesterase 3A, cGMP-inhibited |
Other Description | cAMP phosphodiesterase, myocardial cGMP-inhibited|cGMP-inhibited 3',5'-cyclic phosphodiesterase A|cyclic GMP-inhibited phosphodiesterase A |
Swissprots | O60865 Q14432 Q17RD1 Q13348 |
Accessions | EAW96406 Q14432 AJ005036 CAA06304 AK095203 AK308317 BC117369 AAI17370 BC117371 AAI17372 BQ024709 BQ187047 BX646774 M91667 AAA35912 U36798 AAB18673 XM_006719086 XP_006719149 NM_000921 NP_000912 NM_001244683 NP_001231612 |
Function | Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Top Pathways | Morphine addiction, cGMP-PKG signaling pathway, cAMP signaling pathway, Purine metabolism |
PDE3A CRISPR/Cas9 KO Plasmid (h) - sc-402183 from Santa Cruz Biotechnology
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PDE3A HDR Plasmid (h) - sc-402183-HDR from Santa Cruz Biotechnology
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PDE3A Double Nickase Plasmid (h) - sc-402183-NIC from Santa Cruz Biotechnology
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PDE3A Double Nickase Plasmid (h2) - sc-402183-NIC-2 from Santa Cruz Biotechnology
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PDE3A CRISPR Activation Plasmid (h) - sc-402183-ACT from Santa Cruz Biotechnology
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PDE3A CRISPR Activation Plasmid (h2) - sc-402183-ACT-2 from Santa Cruz Biotechnology
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PDE3A Lentiviral Activation Particles (h) - sc-402183-LAC from Santa Cruz Biotechnology
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PDE3A Lentiviral Activation Particles (h2) - sc-402183-LAC-2 from Santa Cruz Biotechnology
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PDE3A siRNA (h) - sc-41592 from Santa Cruz Biotechnology
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PDE3A shRNA Plasmid (h) - sc-41592-SH from Santa Cruz Biotechnology
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PDE3A shRNA (h) Lentiviral Particles - sc-41592-V from Santa Cruz Biotechnology
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PDE3A RNAi - H00005139-R01 from Novus Biologicals
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MISSION® esiRNA - EHU068261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16534 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16534 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06108 from Sigma-Aldrich
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PDE3A siRNA (Human) - CRH3419 from Cohesion Biosciences
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shRNA set against Human PDE3A (NM_000921.4) - SHH372404 from Creative biogene
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PDE3A shRNA Plasmid (Human) - CHH3419 from Cohesion Biosciences
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PDE3A miRNA 3'UTR clone - MiUTR3H-00559 from Creative biogene
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