TRPM6

Gene Symbol TRPM6
Entrez Gene 140803
Alt Symbol CHAK2, HMGX, HOMG, HOMG1, HSH
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily M, member 6
Other Description channel kinase 2|melastatin-related TRP cation channel 6|transient receptor potential cation channel subfamily M member 6
Swissprots Q6VPS2 Q6VPR9 Q6VPS1 Q9BX84 Q6VPS0 Q6VPR8
Accessions EAW62553 EAW62554 EAW62555 EAW62556 EAW62557 EAW62558 EAW62559 EAW62560 EAW62561 EAW62562 EAW62563 Q9BX84 AF350881 AAK31202 AF448232 AAM21562 AK000094 BAA90941 AK026281 BAB15429 AK057748 BAB71558 AK225207 AY333282 AAR03487 AY333283 AAR03488 AY333284 AAR03489 AY333285 AAR03490 AY333286 AAR03491 AY333287 AAR03492 AY333288 AAR03493 BC156137 AAI56138 XM_011518244 XP_011516546 XM_011518245 XP_011516547 XM_011518246 XP_011516548 XM_011518247 XP_011516549 XM_011518248 XP_011516550 XM_011518249 XP_011516551 XM_011518250 XP_011516552 XM_011518251 XP_011516553 XM_011518252 XP_011516554 XM_011518253 XP_011516555 XM_011518254 XP_011516556 XM_011518255 XP_011516557 XR_929716 XR_929717 XR_929718 NM_001177310 NP_001170781 NM_001177311 NP_001170782 NM_017662 NP_060132
Function Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23942199}; Multi-pass membrane protein.
Tissue Specificity Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells.
Top Pathways Mineral absorption

TRPM6 (D-6) - sc-365536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRPM6 (D-6): sc-365536. Western blot analysis of TRPM6 expression in human kidney tissue extract.

TRPM6 (H-300) - sc-98695 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRPM6 (H-300): sc-98695. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes and bile duct cells.

TRPM6 (S-18) - sc-79795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TRPM6 antibody - ab63089 from Abcam

Host Rabbit
Clonality Polyclonal
ab63089 stained A498 cells. The cells were 4% formaldehyde fixed for 10 minutes at room temperature and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1hour at room temperature to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab63089 at 1/200 dilution) overnight at +4°C. The secondary antibody (pseudo-colored green) was Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed (ab150081) used at a 1/1000 dilution for 1hour at room temperature. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1hour at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-TRPM6 antibody - ab62990 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPM6 antibody - ab72153 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPM6 Antibody (Internal, AP) - LS-C246242 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM6 Antibody (Internal, APC) - LS-C246243 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM6 Antibody (Internal, Biotin) - LS-C246244 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM6 Antibody (Internal, FITC) - LS-C246246 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM6 Antibody (Internal, PE) - LS-C246247 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM6 Antibody (Internal, Azide-free, HRP) - LS-C247945 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM6 Antibody (Internal) - LS-C330711 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

TRPM6 Antibody - NB110-75000 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

TRPM6 Antibody - NB100-98868 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRPM6 Antibody - NBP1-85640 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: TRPM6 Antibody [NBP1-85640] - Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

TRPM6 Polyclonal Antibody - bs-9048R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-TRPM6 (CHAK2) (CENTER) antibody produced in rabbit - SAB1303325 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM6 antibody produced in rabbit - HPA007037 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRPM6: <B>Cat. No. HPA007037</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human duodenal tissue showing cytoplasmic staining of glandular cells.

TRPM6-CHAK2-Antibody-Center - AP8053c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
CHAK2 Antibody (H332) (Cat. #AP8053c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CHAK2 antibody detected the CHAK2 protein (arrow).

TRPM6 Antibody - middle region (OAAB17412) - OAAB17412 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

TRPM6 Antibody - abx033842 from Abbexa

Host Rabbit
Clonality Polyclonal

TRPM6 / CHAK2 antibody - 55455-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of HEK-293 cells using 55455-1-AP( TRPM6 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG

TRPM6 / CHAK2 antibody - PAB3252 from Acris Antibodies

Prices $420.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with TRPM6 polyclonal antibody ( Cat # PAB3252 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.

Guinea Pig Anti-TRPM6 - 114-10051 from RayBiotech

Host Pig
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