TRPM6

Gene Symbol TRPM6
Entrez Gene 140803
Alt Symbol CHAK2, HMGX, HOMG, HOMG1, HSH
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily M, member 6
Other Description channel kinase 2|melastatin-related TRP cation channel 6|transient receptor potential cation channel subfamily M member 6
Swissprots Q6VPS2 Q6VPR9 Q6VPS1 Q9BX84 Q6VPS0 Q6VPR8
Accessions EAW62553 EAW62554 EAW62555 EAW62556 EAW62557 EAW62558 EAW62559 EAW62560 EAW62561 EAW62562 EAW62563 Q9BX84 AF350881 AAK31202 AF448232 AAM21562 AK000094 BAA90941 AK026281 BAB15429 AK057748 BAB71558 AK225207 AY333282 AAR03487 AY333283 AAR03488 AY333284 AAR03489 AY333285 AAR03490 AY333286 AAR03491 AY333287 AAR03492 AY333288 AAR03493 BC156137 AAI56138 XM_011518244 XP_011516546 XM_011518245 XP_011516547 XM_011518246 XP_011516548 XM_011518247 XP_011516549 XM_011518248 XP_011516550 XM_011518249 XP_011516551 XM_011518250 XP_011516552 XM_011518251 XP_011516553 XM_011518252 XP_011516554 XM_011518253 XP_011516555 XM_011518254 XP_011516556 XM_011518255 XP_011516557 XR_929716 XR_929717 XR_929718 NM_001177310 NP_001170781 NM_001177311 NP_001170782 NM_017662 NP_060132
Function Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23942199}; Multi-pass membrane protein.
Tissue Specificity Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells.
Top Pathways Mineral absorption

TRPM6 CRISPR/Cas9 KO Plasmid (h) - sc-416367 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPM6 HDR Plasmid (h) - sc-416367-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPM6 Double Nickase Plasmid (h) - sc-416367-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPM6 Double Nickase Plasmid (h2) - sc-416367-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPM6 CRISPR Activation Plasmid (h) - sc-416367-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPM6 CRISPR Activation Plasmid (h2) - sc-416367-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPM6 Lentiviral Activation Particles (h) - sc-416367-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPM6 Lentiviral Activation Particles (h2) - sc-416367-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPM6 siRNA (h) - sc-76754 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPM6 shRNA Plasmid (h) - sc-76754-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPM6 shRNA (h) Lentiviral Particles - sc-76754-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU078621 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK2348 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2349 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2350 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2427 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2427 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TRPM6 siRNA (Human) - CRJ5323 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPM6 RNAi - H00140803-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TRPM6 - MBS8231450 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TRPM6 (NM_017662.4) - SHH435684 from Creative biogene

Category siRNA
Species Reactivities Human

Human TRPM6 siRNA - orb275824 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPM6 shRNA Plasmid (Human) - CHJ5323 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TRPM6 miRNA 3'UTR clone - MiUTR4H-TG09403 from Creative biogene

Species Reactivities Human
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