Gene Symbol | COL13A1 |
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Entrez Gene | 1305 |
Alt Symbol | COLXIIIA1 |
Species | Human |
Gene Type | protein-coding |
Description | collagen, type XIII, alpha 1 |
Other Description | collagen alpha-1(XIII) chain |
Swissprots | Q13996 A6NFR5 Q7KZ49 Q13993 Q9NQ52 E7EWL8 Q5TAT6 Q13995 Q13992 Q13994 B9EGD2 Q5TAT5 Q7KZ33 Q99228 Q5TAT4 |
Accessions | AAA51987 AAA51988 AAA51989 AAA51990 AAA51991 AAA52754 AAD48082 EAW54333 EAW54334 EAW54335 EAW54336 EAW54337 EAW54338 EAW54339 EAW54340 EAW54341 EAW54342 EAW54343 EAW54344 EAW54345 EAW54346 EAW54347 EAW54348 EAW54349 EAW54350 EAW54351 EAW54352 EAW54353 EAW54354 EAW54355 EAW54356 EAW54357 EAW54358 EAW54359 EAW54360 EAW54361 EAW54362 EAW54363 EAW54364 EAW54365 EAW54366 EAW54367 EAW54368 EAW54369 EAW54370 Q5TAT6 AI741175 AJ293624 CAC00688 AK124476 BC136385 AAI36386 BC139913 BM744248 BY796799 CN297094 M15524 AAA52048 M33653 AAA52047 M59217 AAA51685 XM_011539292 XP_011537594 XM_011539293 XP_011537595 XM_011539294 XP_011537596 XM_011539295 XP_011537597 XM_011539296 XP_011537598 NM_001130103 NP_001123575 NM_080798 NP_542988 NM_080800 NP_542990 NM_080801 NP_542991 NM_080802 NP_542992 NM_080805 NP_542995 NM_005203 NM_080799 NM_080803 NM_080804 NM_080806 NM_080807 NM_080808 NM_080809 NM_080810 NM_080811 NM_080812 NM_080813 NM_080814 NM_080815 |
Function | Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. {ECO:0000250|UniProtKB:Q9R1N9, ECO:0000269|PubMed:10865988, ECO:0000269|PubMed:11956183}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:11013208}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9R1N9, ECO:0000269|PubMed:11013208}. |
Tissue Specificity | Widely expressed in both fetal and adult ocular tissues (at protein level). In the eye, expression is accentuated in the ciliary muscle, optic nerve and the neural retina. In early placenta, localized to fibroblastoid stromal cells of the placental villi, to endothelial cells of developing capillaries and to cells of the cytotrophoblastic columns. Also detected in large decidual cells of the decidual membrane and to stromal cells of the gestational endometrium, but not in the epithelial cells in the endometrial glands. {ECO:0000269|PubMed:10865988, ECO:0000269|PubMed:8246446}. |
Top Pathways | Protein digestion and absorption |
COL13A1 CRISPR/Cas9 KO Plasmid (h) - sc-405731 from Santa Cruz Biotechnology
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COL13A1 HDR Plasmid (h) - sc-405731-HDR from Santa Cruz Biotechnology
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COL13A1 Double Nickase Plasmid (h) - sc-405731-NIC from Santa Cruz Biotechnology
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COL13A1 Double Nickase Plasmid (h2) - sc-405731-NIC-2 from Santa Cruz Biotechnology
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COL13A1 CRISPR Activation Plasmid (h) - sc-405731-ACT from Santa Cruz Biotechnology
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COL13A1 CRISPR Activation Plasmid (h2) - sc-405731-ACT-2 from Santa Cruz Biotechnology
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COL13A1 Lentiviral Activation Particles (h) - sc-405731-LAC from Santa Cruz Biotechnology
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COL13A1 Lentiviral Activation Particles (h2) - sc-405731-LAC-2 from Santa Cruz Biotechnology
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COL13A1 siRNA (h) - sc-90350 from Santa Cruz Biotechnology
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COL13A1 shRNA Plasmid (h) - sc-90350-SH from Santa Cruz Biotechnology
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COL13A1 shRNA (h) Lentiviral Particles - sc-90350-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU099681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6370 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6370 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12143 from Sigma-Aldrich
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COL13A1 siRNA (Human) - CRH0918 from Cohesion Biosciences
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COL13A1 - MBS828535 from MyBioSource
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shRNA set against Human Col13a1 (NM_001130103.1) - SHH267053 from Creative biogene
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COL13A1 shRNA Plasmid (Human) - CHH0918 from Cohesion Biosciences
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