Chek2

Gene Symbol Chek2
Entrez Gene 50883
Alt Symbol CHK2, Cds1, HUCDS1, Rad53
Species Mouse
Gene Type protein-coding
Description checkpoint kinase 2
Other Description CHK2 checkpoint homolog|Cds1 homolog|Rad53 homolog|protein kinase Chk2|serine/threonine-protein kinase Chk2
Swissprots Q9Z265
Accessions EDL19997 EDL19998 Q9Z265 AF086905 AAC83694 AK044913 BAC32138 AK169781 AK170235 BC056617 AAH56617 XM_006535067 XP_006535130 XM_006535068 XP_006535131 XM_006535069 XP_006535132 XM_006535070 XP_006535133 XM_006535071 XP_006535134 XM_006535072 XP_006535135 XM_011249509 XP_011247811 XR_880398 NM_016681 NP_057890
Function Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphor
Subcellular Location Nucleus, PML body {ECO:0000250}. Nucleus, nucleoplasm. Note=Recruited into PML bodies together with TP53. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed with higher levels in the thymus, spleen and colon (at protein level). {ECO:0000269|PubMed:12192050}.
Top Pathways Cell cycle, p53 signaling pathway, HTLV-I infection

Chk2 (S-19) - sc-8814 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Chk2 (S-19): sc-8814. Immunofluorescence staining of methanol-fixed WEHI-231 cells showing nuclear localization.

Chk2 Antibody (235303) - MAB22851 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 235303
Western blot shows lysates of Balb/3T3 mouse embryonic fibroblast cell line and C2C12 mouse myoblast cell line. PVDF membrane was probed with 2 µg/mL of Rat Anti-Mouse Chk2 Monoclonal Antibody (Catalog # MAB22851) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for Chk2 at approximately 61 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Chk2 antibody - 70R-33387 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Chk2 antibody - 70R-35095 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Chk2 antibody - 70R-36675 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Chk2 antibody (Thr387) - 70R-30869 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Chk2 antibody (Thr68) - 70R-34982 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Chk2 antibody (Thr68) - 70R-37142 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Chk2 antibody - 70R-30870 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

CHK2 antibody (Thr387) - 70R-37428 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Chk2 antibody (Thr383) - 70R-33386 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Chk2 antibody - 70R-37527 from Fitzgerald

Prices $225.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Chk2 Checkpoint Homolog (S. Pombe) Antibody - abx111593 from Abbexa

Prices $490.00, $490.00, $490.00, $490.00
Sizes 10 μl, 50 μl, 100 μl, 200 μl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-Human Chk2 (N-term) - DS-PB-00461 from RayBiotech

Host Rabbit

Rabbit Anti-Human Chk2 (N-term) - DS-PB-02440 from RayBiotech

Host Rabbit

CHK2 / CHEK2 Antibody, Rabbit PAb, Antigen Affinity Purified - 50432-RP02-50 from Sino Biological

Prices $170.00, $290.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

CHEK2 Antibody - CSB-PA005339GA01HU from Cusabio

Host Rabbit

CHK2 antibody - orb170834 from Biorbyt

Prices $323.00, $442.00, $570.00
Sizes 50 μg, 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal

Mouse Chek2 antibody - C - terminal region (OAAB11036) - OAAB11036 from Aviva Systems Biology

Host Rabbit
Clonality Polyclonal
Search more