| Gene Symbol |
Chek2
|
| Entrez Gene |
50883
|
| Alt Symbol |
CHK2, Cds1, HUCDS1, Rad53
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
checkpoint kinase 2
|
| Other Description |
CHK2 checkpoint homolog|Cds1 homolog|Rad53 homolog|protein kinase Chk2|serine/threonine-protein kinase Chk2
|
| Swissprots |
Q9Z265
|
| Accessions |
EDL19997 EDL19998 Q9Z265 AF086905 AAC83694 AK044913 BAC32138 AK169781 AK170235 BC056617 AAH56617 XM_006535067 XP_006535130 XM_006535068 XP_006535131 XM_006535069 XP_006535132 XM_006535070 XP_006535133 XM_006535071 XP_006535134 XM_006535072 XP_006535135 XM_011249509 XP_011247811 XR_880398 NM_016681 NP_057890
|
| Function |
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphor
|
| Subcellular Location |
Nucleus, PML body {ECO:0000250}. Nucleus, nucleoplasm. Note=Recruited into PML bodies together with TP53. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed with higher levels in the thymus, spleen and colon (at protein level). {ECO:0000269|PubMed:12192050}.
|
| Top Pathways |
Cell cycle, p53 signaling pathway, HTLV-I infection
|