UMOD

Gene Symbol UMOD
Entrez Gene 7369
Alt Symbol ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP
Species Human
Gene Type protein-coding
Description uromodulin
Other Description Tamm-Horsfall urinary glycoprotein|uromucoid
Swissprots Q6ZS84 B3KP48 B3KRN9 P07911 Q540J6 Q8IYG0 E9PEA4
Accessions AAL27853 AAO64446 EAW50314 EAW50315 P07911 AK055722 BAG51560 AK091961 BAG52451 AK096043 BAG53202 AK127643 BAC87070 AK127648 BAG54541 BC035975 AAH35975 BF593229 BG428950 DA634392 M15881 AAA36798 M17778 AAA36799 XM_011545934 XP_011544236 XM_011545935 XP_011544237 XM_011545936 XP_011544238 XM_011545937 XP_011544239 XM_011545938 XP_011544240 XM_011545939 XP_011544241 XM_011545940 XP_011544242 NM_001008389 NP_001008390 NM_001278614 NP_001265543 NM_003361 NP_003352
Function Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial. {ECO:0000269|PubMed:20798515}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:22776760, ECO:0000269|PubMed:23988501}; Lipid- anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI- anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization. Secreted into urine after cleavage. Colocalized with NPHP1 and KIF3A.
Tissue Specificity Expressed in the tubular cells of the kidney (at protein level). Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen. Most abundant protein in normal urine. {ECO:0000269|PubMed:22776760, ECO:0000269|PubMed:23988501, ECO:0000269|PubMed:7028707}.

THP (B-2) - sc-271022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
THP (B-2): sc-271022. Western blot analysis of THP expression in non-transfected: sc-117752 (A) and mouse THP transfected: sc-127653 (B) 293T whole cell lysates.

THP (D-20) - sc-19552 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
THP (D-20): sc-19552. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells.

THP (H-135) - sc-20631 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
THP (H-135): sc-20631. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

THP (Q-20) - sc-19551 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Uromucoid antibody - ab167678 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Uromucoid antibody (ab167678) at 1 µg/mlLane 1 : Uromucoid transfected 293T cell lysateLane 2 : Non-transfected transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-Uromucoid antibody - ab167001 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Uromucoid antibody - ab190074 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-Uromucoid antibody (ab190074) at 1/1000 dilution + MDA-MB453 cell line lysate at 35 µg

Anti-Uromucoid antibody - ab166986 from Abcam

Host Sheep
Clonality Polyclonal

Anti-Uromucoid antibody - ab123319 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Uromucoid antibody (ab123319) at 1/100 dilution + MDA-MB453 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-Uromucoid antibody - ab135992 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Uromucoid antibody (ab135992) at 1/500 dilution + K562 cell extract at 30 µg

Anti-Uromucoid antibody - ab156827 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Uromucoid antibody (ab156827) at 0.5 µg/ml + HeLa cell lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-Uromucoid antibody - ab9029 from Abcam

Prices $368.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-Uromucoid antibody - ab53588 from Abcam

Prices $359.00
Sizes 500 µl
Host Sheep
Clonality Polyclonal

Anti-Uromucoid antibody - C-terminal - ab156831 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Uromucoid antibody - C-terminal (ab156831) at 0.03 µg/ml + HeLa cell lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-UMOD / Uromodulin Antibody - LS-C39481 from LifeSpan Bioscience

Prices $445.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-UMOD / Uromodulin Antibody - LS-C39484 from LifeSpan Bioscience

Prices $405.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-UMOD / Uromodulin Antibody - LS-C39485 from LifeSpan Bioscience

Prices $465.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-UMOD / Uromodulin Antibody - LS-C39482 from LifeSpan Bioscience

Prices $515.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-UMOD / Uromodulin Antibody - LS-C42169 from LifeSpan Bioscience

Prices $390.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-UMOD / Uromodulin Antibody - LS-C40106 from LifeSpan Bioscience

Prices $415.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-UMOD / Uromodulin Antibody (clone 10.32, HRP) - LS-C62647 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 10.32

Anti-UMOD / Uromodulin Antibody - LS-C85704 from LifeSpan Bioscience

Prices $475.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-UMOD / Uromodulin Antibody (Biotin) - LS-C39486 from LifeSpan Bioscience

Prices $465.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-UMOD / Uromodulin Antibody (clone 10.32) - LS-C62644 from LifeSpan Bioscience

Prices $365.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone 10.32

Anti-UMOD / Uromodulin Antibody (aa24-618) - LS-C126349 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
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