UMOD

Gene Symbol	UMOD
Entrez Gene	7369
Alt Symbol	ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP
Species	Human
Gene Type	protein-coding
Description	uromodulin
Other Description	Tamm-Horsfall urinary glycoprotein|uromucoid
Swissprots	Q6ZS84 B3KP48 B3KRN9 P07911 Q540J6 Q8IYG0 E9PEA4
Accessions	AAL27853 AAO64446 EAW50314 EAW50315 P07911 AK055722 BAG51560 AK091961 BAG52451 AK096043 BAG53202 AK127643 BAC87070 AK127648 BAG54541 BC035975 AAH35975 BF593229 BG428950 DA634392 M15881 AAA36798 M17778 AAA36799 XM_011545934 XP_011544236 XM_011545935 XP_011544237 XM_011545936 XP_011544238 XM_011545937 XP_011544239 XM_011545938 XP_011544240 XM_011545939 XP_011544241 XM_011545940 XP_011544242 NM_001008389 NP_001008390 NM_001278614 NP_001265543 NM_003361 NP_003352
Function	Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial. {ECO:0000269|PubMed:20798515}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:22776760, ECO:0000269|PubMed:23988501}; Lipid- anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI- anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization. Secreted into urine after cleavage. Colocalized with NPHP1 and KIF3A.
Tissue Specificity	Expressed in the tubular cells of the kidney (at protein level). Synthesized exclusively in the kidney. Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen. Most abundant protein in normal urine. {ECO:0000269|PubMed:22776760, ECO:0000269|PubMed:23988501, ECO:0000269|PubMed:7028707}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cat Uromucoid full length protein - ab167968 from Abcam Category Protein Prices $1,049.00 Sizes 50 µg Source Native Species Cat

Dog Uromucoid full length protein - ab168879 from Abcam Category Protein Prices $1,049.00 Sizes 100 µg Source Native Species Dog

Human Uromucoid full length protein - ab91031 from Abcam Category Protein Source Native Species Human

Human Uromucoid full length protein - ab96035 from Abcam Category Protein Source Native Species Human

Human Uromucoid protein fragment - ab152789 from Abcam Category Protein Source Wheat germ Species Human

UMOD / Uromodulin Antibody Blocking Peptide - LS-E3117 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UMOD / Uromodulin Antibody Blocking Peptide - LS-E27944 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UMOD / Uromodulin Antibody Blocking Peptide - LS-E27945 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Uromodulin Partial Recombinant Protein - H00007369-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UMOD-Antibody-Center-Blocking-Peptide - BP14256c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UMOD Human - Human Uromodulin Protein (OPPA01799) - OPPA01799 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Human Urine Species Human

Human UMOD protein - orb90304 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source Human Urine Species Human

UMOD Immunizing peptide - orb66446 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

UMOD Blocking Peptide - 33R-7383 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Uromodulin Blocking Peptide - 33R-6556 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Uromodulin Protein - abx069612 from Abbexa Category Protein Source E.coli Species Human

Uromodulin Blocking Peptide - abx063405 from Abbexa Category Peptide Species Human

Uromucoid Peptide - AC21-2713-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Uromucoid Peptide - AC21-2714-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Uromodulin (UMOD) - H00007369-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Uromodulin (UMOD) - H00007369-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Uromodulin (UMOD) - H00007369-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Uromodulin (UMOD) - H00007369-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Uromodulin (UMOD) - P135-1 from Acris Antibodies Category Protein Prices $440.00 Sizes 1 mg Source Urine Species Human

Uromodulin Human - 228-11596-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Human Urine. Species Human

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