NF1

Gene Symbol NF1
Entrez Gene 4763
Alt Symbol NFNS, VRNF, WSS
Species Human
Gene Type protein-coding
Description neurofibromin 1
Other Description neurofibromatosis-related protein NF-1|neurofibromin
Swissprots P21359 Q14931 Q9UMK3 Q14930 Q14284 O00662
Accessions AAA56765 AAB26693 AAB26694 AAB48373 AAB48374 AAB48375 AAB48376 AAB48377 AAB48378 AAB48379 AAB48380 AAD13890 AAD14922 AAS67035 AAV50004 BAD98998 BAD98999 CAA52021 CAA69179 EAW80267 EAW80268 EAW80269 EAW80270 EAW80271 EAW80272 EAW80273 EAW80274 EAW80275 P21359 AB209336 BAD92573 AF055023 AF086346 AK024873 AK026658 AK289936 BAF82625 AK301970 BAG63383 AK302063 BAG63453 BC144643 BP271334 BX391799 BX537850 CAD97858 CN415204 D10490 BAA01371 D12625 BAA02150 D42072 BAA07669 DA299151 DB094344 M38106 AAA74897 M38107 AAB59558 M60496 AAA59928 M60915 AAA59921 M61213 AAA59923 M82814 AAA59924 M89914 AAA59925 S51751 AAB24636 XM_005257983 XP_005258040 XM_005257984 XP_005258041 XM_006721922 XP_006721985 XM_006721923 XP_006721986 XM_006721924 XP_006721987 XM_006721925 XP_006721988 XM_006721926 XP_006721989 XM_006721927 XP_006721990 XM_006721928 XP_006721991 XM_011524852 XP_011523154 XM_011524853 XP_011523155 XM_011524854 XP_011523156 XM_011524855 XP_011523157 XM_011524856 XP_011523158 XM_011524857 XP_011523159 NM_000267 NP_000258 NM_001042492 NP_001035957 NM_001128147 NP_001121619
Function Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}.
Subcellular Location Nucleus {ECO:0000269|PubMed:14988005}. Nucleus, nucleolus {ECO:0000269|PubMed:14988005}.
Tissue Specificity Detected in brain, peripheral nerve, lung, colon and muscle. {ECO:0000269|PubMed:8417346}.
Top Pathways MAPK signaling pathway

Neurofibromin (E-8) - sc-398267 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neurofibromin (E-8): sc-398267. Western blot analysis of Neurofibromin expression in HeLa (A) and Hep G2 (B) whole cell lysates and rat brain tissue extract (C).

Neurofibromin (D) - sc-67 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Neurofibromin (D): sc-67. Western blot analysis of Neurofibromin expression in A-431 (A) and HeLa (B) whole cell lysates.

Neurofibromin (H-12) - sc-376886 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neurofibromin (H-12): sc-376886. Western blot analysis of Neurofibromin expression in LNCaP whole cell lysate.

Neurofibromin (1-300) - sc-20982 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Neurofibromin (1-300): sc-20982. Immunofluorescence staining of normal mouse lymph node frozen section showing cytoplasmic staining.

Neurofibromin (H-300) - sc-20683 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Neurofibromin (H-300): sc-20683. Immunofluorescence staining of normal mouse kidney frozen section showing cytoskeletal staining.

Neurofibromin (McNFn27a) - sc-20017 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neurofibromin (McNFn27a): sc-20017. Western blot analysis of Neurofibromin expression in NF1 knockout (A), rat (B) and human (C) Schwann cells. Kindly provided by Dr. David Muir, University of Florida College of Medicine.

Neurofibromin (McNFn27b) - sc-20016 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neurofibromin (McNFn27b): sc-20016. Immunofluorescence staining of methanol-fixed H4 cells showing cytoplasmic staining.

Neurofibromin (N) - sc-68 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of human recombinant Neurofibromin fusion protein (A,B). Antibodies tested include: Neurofibromin (H-300): sc-20683 (A) and Neurofibromin (N): sc-68 (B).

p-Neurofibromin (Ser 2515) - sc-130208 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Neurofibromin antibody - ab30325 from Abcam

Prices $392.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab30325 at a 1/500 dilution, staining human Neurofibromin in human dorsal ganglion neurons by Immunohistochemistry, Formalin fixed Paraffin embedded tissue.

Anti-Neurofibromin antibody - ab128054 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Neurofibromin antibody (ab128054) at 1/500 dilutionLane 1 : HepG2 cells extractLane 2 : HepG2 cells extract with synthesized peptide

Anti-Neurofibromin antibody [McNFn27b] - N-terminal - ab178323 from Abcam

Prices $384.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone McNFn27b
Immunofluorescent analysis of formaldehyde-fixed U251 cells labeling Neurofibromin with ab178323 at 1/20 dilution (green, left image) or a control (right image) followed with a DyLight-488 conjugated secondary antibody. F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue).

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27a, Biotin) - LS-C142055 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27a

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27a, DY650) - LS-C142056 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27a

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27a, DY488) - LS-C142057 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27a

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27a, HRP) - LS-C142058 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27a

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27a, DY550) - LS-C142059 from LifeSpan Bioscience

Prices $365.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27a

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27b, DY488) - LS-C142062 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27b

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27b, Biotin) - LS-C142060 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27b

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27b, DY650) - LS-C142061 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27b

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27b, HRP) - LS-C142063 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27b

Anti-Neurofibromin / NF1 Antibody (N-Terminus, clone McNFn27b, DY550) - LS-C142064 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27b

Anti-Neurofibromin / NF1 Antibody (aa27-41, clone McNFn27a) - LS-C2721 from LifeSpan Bioscience

Prices $335.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone McNFn27a
Specificity of Neurofibromin, using LS-C2721, in Schwann cells from embryonic knockout mice, adult human nerves and neonatal rat nerves.

Anti-Neurofibromin / NF1 Antibody (aa2506-2600) - LS-C311862 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NFIA / Nuclear Factor 1 Antibody (Gln34) - LS-C176802 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of NF-1 (Q34) pAb in extracts from raw264.7 cells.
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