MLLT4

Gene Symbol MLLT4
Entrez Gene 4301
Alt Symbol AF6
Species Human
Gene Type protein-coding
Description myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Other Description ALL1-fused gene from chromosome 6 protein|afadin|protein AF-6
Swissprots Q5TIG7 O75088 O75089 Q9NU92 P55196 Q5TIG6 O75087 Q59FP0 Q9NSN7
Accessions BAA32483 BAA32484 BAA32485 EAW47480 EAW47481 EAW47482 EAW47483 EAW47484 EAW47485 EAW47486 P55196 AB209420 BAD92657 AB621809 BAK64145 AF085836 AI271860 AK055689 AK091815 AL161973 CAB82312 BC014505 AAH14505 BC156048 AAI56049 BC156934 AAI56935 BE503462 BE645141 BF732725 BQ646972 BX649158 CA503365 D60168 DA200453 DB079271 S82521 AAB37466 U02478 AAC50059 XM_005266996 XP_005267053 XM_005266997 XP_005267054 XM_006715491 XP_006715554 XM_006715492 XP_006715555 XM_006715493 XP_006715556 XM_006715494 XP_006715557 XM_011535840 XP_011534142 XM_011535841 XP_011534143 XM_011535842 XP_011534144 XM_011535843 XP_011534145 NM_001040000 NP_001035089 NM_001207008 NP_001193937 NM_001291964 NP_001278893 NM_001040001 NM_005936
Function Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
Subcellular Location Cell junction, adherens junction. Note=Not found at cell-matrix AJs.
Top Pathways Adherens junction, Tight junction, Leukocyte transendothelial migration, cAMP signaling pathway, Rap1 signaling pathway

Phospho-Afadin (Ser1718) Antibody - 5485 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A431 cells, untreated or EGF-treated (100 ng/ml for 5 minutes), using Phospho-Afadin (Ser1718) Antibody.

Afadin Antibody - 6492 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Afadin Antibody.

Afadin (D1Y3Z) Rabbit mAb - 13531 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1Y3Z
Western blot analysis of extracts from various cell lines using Afadin (D1Y3Z) Rabbit mAb.

AF-6 (B-5) - sc-74433 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AF-6 (B-5): sc-74433. Western blot analysis of AF-6 expression in SK-N-MC (A), IMR-32 (B) and NIH/3T3 (C) whole cell lysates.

AF-6 (C-3) - sc-74432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AF-6 (C-3): sc-74432. Western blot analysis of AF-6 expression in SK-N-MC (A), IMR-32 (B) and NIH/3T3 (C) whole cell lysates.

AF-6 (C-15) - sc-14810 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AF-6 (C-15): sc-14810. Western blot analysis of AF-6 expression in non-transfected: sc-110760 (A) and mouse AF-6 transfected: sc-178260 (B) 293 whole cell lysates.

AF-6 (H-106) - sc-28656 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AF-6 (H-106): sc-28656. Western blot analysis of AF-6 expression in non-transfected: sc-110760 (A) and mouse AF-6 transfected: sc-178260 (B) 293 whole cell lysates.

AF-6 (P-18) - sc-14808 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AF-6 (P-18): sc-14808. Western blot analysis of AF-6 expression in non-transfected: sc-110760 (A) and mouse AF-6 transfected: sc-178260 (B) 293 whole cell lysates.

AF-6 (35) - sc-135823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
AF-6 (35): sc-135823. Western blot analysis of AF-6 expression in PC-12 whole cell lysate.

AF-6 (G-7) - sc-398370 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AF-6 (G-7): sc-398370. Western blot analysis of AF-6 expression in non-transfected 293: sc-110760 (A), mouse AF-6 transfected 293: sc-178260 (B), SK-N-MC (C), Hep G2 (D), PC-12 (E) and NIH/3T3 (F) whole cell lysates.

Anti-l + S Afadin antibody - ab189211 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded, formalin-fixed Human spleen tissue labeling l + S Afadin using ab189211 at 5 µg/ml, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-l + S Afadin antibody - N-terminal - ab166660 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-l + S Afadin antibody - N-terminal (ab166660) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-l + S Afadin antibody - ab11338 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-l Afadin antibody - ab11337 from Abcam

Prices $380.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-l Afadin antibody (ab11337) at 1/1000 dilutionLane 1 : Mouse hippocampal lysatesLane 2 : Mouse hippocampal lysatesLane 3 : Mouse hippocampal lysates (boiled)Lane 4 : Mouse hippocampal lysates (boiled)Lysates/proteins at 40 µg per lane.SecondaryHRP-conjugated goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL techniquePerformed under non-reducing conditions.Observed band size : 200 kDa (why is the actual band size different from the predicted?)Exposure time : 10 minutest\his image is courtesy of an Anonymous Abreview.See Abreview

Anti-l Afadin antibody [3] - ab90809 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3

Anti-MLLT4 / Afadin Antibody (aa1582-1597) IHC-plus™ - LS-B871 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MLLT4 / Afadin antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B871 concentration 5 ug/ml.

Anti-MLLT4 / Afadin Antibody (clone 3) - LS-C140164 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3

Anti-MLLT4 / Afadin Antibody (aa1475-1525) - LS-C288953 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT4 / Afadin Antibody (phospho-Ser1718) - LS-C183743 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT4 / Afadin Antibody (aa1774-1824) - LS-C288954 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MLLT4 / Afadin Antibody (aa152-201) - LS-C40296 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, HepG2 Cell Lysate

Anti-MLLT4 / Afadin Antibody (N-Terminus) IHC-plus™ - LS-B7272 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MLLT4 / Afadin antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7272 concentration 5 ug/ml.

Anti-MLLT4 / Afadin Antibody (aa87-136) - LS-C186936 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Jurkat. MLLT4-AS1 antibody dilution 1.0 ug/ml.

Afadin/AF-6 Antibody [Unconjugated] - AF7829 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of HEK293T human embryonic kidney cell line and SK‑OV‑3 human ovarian adenocarcinoma cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Afadin/AF-6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7829) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Afadin/AF-6 at approximately 220 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Afadin/AF-6 Antibody - NBP1-90219 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Afadin/AF-6 Antibody [NBP1-90219] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, plasma membrane & cell junctions.
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