RNF40

Gene Symbol	RNF40
Entrez Gene	9810
Alt Symbol	BRE1B, RBP95, STARING
Species	Human
Gene Type	protein-coding
Description	ring finger protein 40, E3 ubiquitin protein ligase
Other Description	95 kDa retinoblastoma protein binding protein|95 kDa retinoblastoma-associated protein|BRE1 E3 ubiquitin ligase homolog B|BRE1-B|E3 ubiquitin-protein ligase BRE1B|Rb-associated protein
Swissprots	Q8N615 Q7L3T6 Q9BSV9 Q6N005 Q6AHZ6 Q96T18 Q9HC82 O75150
Accessions	EAW52197 EAW52198 EAW52199 EAW52200 O75150 AB014561 BAA31636 AF122819 AAG13723 AI373490 AK027406 BAB55092 AK054773 AK075526 BAG52163 AK131310 BAD18476 AK291666 BAF84355 AK293710 BAG57143 AK294258 BAG57553 AK297531 BAG59933 AK304521 BAG65325 AL708520 AL712808 BC004527 AAH04527 BC006133 AAH06133 BC011769 AAH11769 BC018647 AAH18647 BC030802 AAH30802 BC113827 BM682766 BX640763 CAE45869 CR627431 CAH10518 DA328615 DQ893443 ABM84369 DQ896794 ABM87793 XM_011545997 XP_011544299 XM_011545998 XP_011544300 XM_011545999 XP_011544301 XM_011546000 XP_011544302 NM_001207033 NP_001193962 NM_001207034 NP_001193963 NM_001286572 NP_001273501 NM_014771 NP_055586
Function	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10944455}.
Tissue Specificity	Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. {ECO:0000269|PubMed:10944455}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF40 peptide - ab27759 from Abcam Category Peptide

Human RNF40 peptide - ab27760 from Abcam Category Peptide

Human RNF40 protein fragment - ab160662 from Abcam Category Protein Source Wheat germ Species Human

RNF40 / STARING Antibody Blocking Peptide - LS-E3210 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF40 Partial Recombinant Protein - H00009810-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RNF40-Antibody-C-term-Blocking-Peptide - BP14362b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF40 Blocking Peptide - 33R-4520 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF40 - H00009810-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF40 - H00009810-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF40 fusion protein - Ag8047 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RNF40 fusion protein - ag0953 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RNF40, His-tagged - RNF40-2345H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase BRE1B(RNF40) ,partial - CSB-YP019890HU CSB-EP019890HU CSB-BP019890HU CSB-MP019890HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF40 Recombinant Protein Antigen - NBP1-88356PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF40 Peptide, Human - M34GP13438H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNF40 Recombinant Protein Antigen - NBP2-54968PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

E3 ubiquitin-protein ligase BRE1B (RNF40), partial, Recombinant Protein - MBS1246851 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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