RNF40

Gene Symbol RNF40
Entrez Gene 9810
Alt Symbol BRE1B, RBP95, STARING
Species Human
Gene Type protein-coding
Description ring finger protein 40, E3 ubiquitin protein ligase
Other Description 95 kDa retinoblastoma protein binding protein|95 kDa retinoblastoma-associated protein|BRE1 E3 ubiquitin ligase homolog B|BRE1-B|E3 ubiquitin-protein ligase BRE1B|Rb-associated protein
Swissprots Q8N615 Q7L3T6 Q9BSV9 Q6N005 Q6AHZ6 Q96T18 Q9HC82 O75150
Accessions EAW52197 EAW52198 EAW52199 EAW52200 O75150 AB014561 BAA31636 AF122819 AAG13723 AI373490 AK027406 BAB55092 AK054773 AK075526 BAG52163 AK131310 BAD18476 AK291666 BAF84355 AK293710 BAG57143 AK294258 BAG57553 AK297531 BAG59933 AK304521 BAG65325 AL708520 AL712808 BC004527 AAH04527 BC006133 AAH06133 BC011769 AAH11769 BC018647 AAH18647 BC030802 AAH30802 BC113827 BM682766 BX640763 CAE45869 CR627431 CAH10518 DA328615 DQ893443 ABM84369 DQ896794 ABM87793 XM_011545997 XP_011544299 XM_011545998 XP_011544300 XM_011545999 XP_011544301 XM_011546000 XP_011544302 NM_001207033 NP_001193962 NM_001207034 NP_001193963 NM_001286572 NP_001273501 NM_014771 NP_055586
Function Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19410543}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10944455}.
Tissue Specificity Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. {ECO:0000269|PubMed:10944455}.

RNF40 CRISPR/Cas9 KO Plasmid (h) - sc-404156 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF40 HDR Plasmid (h) - sc-404156-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF40 Double Nickase Plasmid (h) - sc-404156-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF40 Double Nickase Plasmid (h2) - sc-404156-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF40 CRISPR Activation Plasmid (h) - sc-404156-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF40 CRISPR Activation Plasmid (h2) - sc-404156-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF40 Lentiviral Activation Particles (h) - sc-404156-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF40 Lentiviral Activation Particles (h2) - sc-404156-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF40 siRNA (h) - sc-93054 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF40 shRNA Plasmid (h) - sc-93054-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF40 shRNA (h) Lentiviral Particles - sc-93054-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF40 RNAi - H00009810-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RNF40 RNAi - H00009810-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU158131 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18436 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18436 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07731 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07731

RNF40 siRNA (Human) - CRH6566 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF40 - MBS8206753 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF40 (NM_014771.3) - SHH397348 from Creative biogene

Category siRNA
Species Reactivities Human

Human RNF40 siRNA - orb267068 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF40 shRNA Plasmid (Human) - CHH6566 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF40 miRNA 3'UTR clone - MiUTR3H-09391 from Creative biogene

Species Reactivities Human
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