TRPV6

Gene Symbol TRPV6
Entrez Gene 55503
Alt Symbol ABP/ZF, CAT1, CATL, ECAC2, HSA277909, LP6728, ZFAB
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 6
Other Description Alu-binding protein with zinc finger domain|calcium transport protein 1|calcium transporter-like protein|epithelial apical membrane calcium transporter/channel CaT1|epithelial calcium channel 2|transient receptor potential cation channel subfamily V member 6
Swissprots A4D2I8 Q9H1D0 Q96LC5 Q8WXR8 Q8TDL3 Q9H296 Q9H1D1
Accessions AAO38052 EAL23776 EAW51897 EAW51898 EAW51899 Q9H1D0 AF304463 AAG41951 AF365927 AAL40230 AF365928 AAM00356 AJ243500 CAC20416 AJ243501 CAC20417 AJ277909 CAB92352 AJ487964 CAD32311 AK075103 BAC11402 AK075206 BAC11471 AK291707 BAF84396 AW137696 AY203947 AAP34470 BC007094 BC034814 AAH34814 BC113101 BC160161 AAI60161 KF534785 AHA85010 U82613 AAB40152 X83877 CAA58757 NM_018646 NP_061116 NM_014274
Function Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23612980}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91WD2}.
Tissue Specificity Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in trophoblasts of placenta villus trees (at protein level)(PubMed:23612980). Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia. {ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:23612980}.
Top Pathways Salivary secretion, Mineral absorption

TRPV6 (H-90) - sc-28763 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRPV6 (H-90): sc-28763. Western blot analysis of TRPV6 expression in Hep G2 (A), Caco-2 (B), SW480 (C), KNRK (D) and HCT-8 (E) whole cell lysates.

TRPV6 (E-16) - sc-31446 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRPV6 (N-16) - sc-28396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRPV6 (N-16): sc-28396. Western blot analysis of TRPV6 expression in Caco-2 (A), SW480 (B), KNRK (C) and HCT-8 (D) whole cell lysates and mouse kidney tissue extract (E).

TRPV6 (L-15) - sc-31445 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRPV6 (C-16) - sc-19104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TRPV6 antibody - ab63084 from Abcam

Host Rabbit
Clonality Polyclonal
ab63084, staining TRPV6 in equine articular cartilage, by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Sections were blocked with PBS-T and 1% BSA before incubating with primary antibody overnight at 4°C. An HRP-conjugated goat anti-rabbit IgG was used as the secondary antibody and was detected using DAB. Nuclei were counterstained with hematoxylin.

Anti-TRPV6 antibody - ab117875 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPV6 antibody (ab117875) at 1/500 dilution + HEK cell lysate at 50 µg

Anti-TRPV6 antibody - ab64229 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPV6 antibody - ab111941 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRPV6 antibody (ab111941) at 1/500 dilutionLane 1 : Human fetal kidney lysateLane 2 : Human fetal colon lysate

Anti-TRPV6 Antibody (N-Terminus) - LS-C12355 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV6 Antibody - LS-C95000 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPV6 Antibody - LS-C95028 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-TRPV6 Antibody (aa280-329) - LS-C135032 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TRPV6 antibody LS-C135032 Western blot of Rat Brain lysate. Antibody concentration 1 ug/ml.

Anti-TRPV6 Antibody (aa18-37) - LS-C313111 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of TRPV6 antibody. Lane 1: Rat Brain Tissue Lysate. Lane 2: Mouse Brain Tissue Lysate. Lane 3: Mouse Testis Tissue Lysate.

Anti-TRPV6 Antibody (C-Terminus) - LS-C178547 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPV6 Antibody - LS-C331496 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using TRPV6 antibody.

Anti-TRPV6 Antibody (aa352-385) - LS-C344294 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysates from SW480 cell line, human placenta, human liver, kidney and testis tissue lysate (from left to right) with TRPV6 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

TRPV6 Antibody - NBP2-32372 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: TRPV6 Antibody [NBP2-32372] - Staining of human placenta shows cytoplasmic positivity in decidua cells.

TRPV6 Antibody - 43470002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: TRPV6 Antibody [43470002]

TRPV6 Antibody - NB110-75013 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

TRPV6 Antibody - NB110-74952 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-TRPV6 Polyclonal Antibody - bs-15506R from Bioss

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV6 antibody produced in rabbit - T3201 from Sigma-Aldrich

Prices $572.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV6 antibody produced in rabbit - HPA062864 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TRPV6: <B>Cat. No. HPA062864</B>: Immunohistochemical staining of Human testis shows strong cytoplasmic positivity in cells in seminiferus ducts of testis while Leydig cells shows moderate cytoplasmic positivity .

TRPV6-Antibody-Center - AP20671c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from SW480 cell line, human placenta, huamn liver, kidney and testis tissue lysate(from left to right), using TRPV6 Antibody (Center)(Cat. #AP20671c). AP20671c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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