| Gene Symbol |
TRPV6
|
| Entrez Gene |
55503
|
| Alt Symbol |
ABP/ZF, CAT1, CATL, ECAC2, HSA277909, LP6728, ZFAB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily V, member 6
|
| Other Description |
Alu-binding protein with zinc finger domain|calcium transport protein 1|calcium transporter-like protein|epithelial apical membrane calcium transporter/channel CaT1|epithelial calcium channel 2|transient receptor potential cation channel subfamily V member 6
|
| Swissprots |
A4D2I8 Q9H1D0 Q96LC5 Q8WXR8 Q8TDL3 Q9H296 Q9H1D1
|
| Accessions |
AAO38052 EAL23776 EAW51897 EAW51898 EAW51899 Q9H1D0 AF304463 AAG41951 AF365927 AAL40230 AF365928 AAM00356 AJ243500 CAC20416 AJ243501 CAC20417 AJ277909 CAB92352 AJ487964 CAD32311 AK075103 BAC11402 AK075206 BAC11471 AK291707 BAF84396 AW137696 AY203947 AAP34470 BC007094 BC034814 AAH34814 BC113101 BC160161 AAI60161 KF534785 AHA85010 U82613 AAB40152 X83877 CAA58757 NM_018646 NP_061116 NM_014274
|
| Function |
Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:Q91WD2, ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23612980}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91WD2}.
|
| Tissue Specificity |
Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in trophoblasts of placenta villus trees (at protein level)(PubMed:23612980). Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia. {ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:23612980}.
|
| Top Pathways |
Salivary secretion, Mineral absorption
|