| Gene Symbol | Nmnat3 |
|---|---|
| Entrez Gene | 74080 |
| Alt Symbol | 4933408N02Rik, PNAT3 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | nicotinamide nucleotide adenylyltransferase 3 |
| Other Description | NMN adenylyltransferase 3|NMN/NaMN adenylyltransferase 3|naMN adenylyltransferase 1|naMN adenylyltransferase 3|nicotinamide mononucleotide adenylyltransferase 3|nicotinamide-nucleotide adenylyltransferase 3|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3|nicotinate-nucleotide adenylyltransferase 1|nicotinate-nucleotide adenylyltransferase 3 |
| Swissprots | Q99JR6 Q58E37 |
| Accessions | EDL20981 EDL20982 EDL20983 Q99JR6 AK016744 AK040783 AK041526 BAE20591 AK041897 BAE20611 BC005737 AAH05737 BC092086 AAH92086 XM_006511502 XP_006511565 XM_006511503 XP_006511566 XM_006511504 XP_006511567 XM_006511505 XP_006511568 XM_006511506 XP_006511569 XM_006511507 XP_006511570 XM_011242826 XP_011241128 XM_011242827 XP_011241129 NM_144533 NP_653116 |
| Function | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. {ECO:0000269|PubMed:16914673}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:16914673}. |
| Top Pathways | Nicotinate and nicotinamide metabolism |
NMNAT-3 CRISPR/Cas9 KO Plasmid (m) - sc-428711 from Santa Cruz Biotechnology
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NMNAT-3 HDR Plasmid (m) - sc-428711-HDR from Santa Cruz Biotechnology
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NMNAT-3 Double Nickase Plasmid (m) - sc-428711-NIC from Santa Cruz Biotechnology
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NMNAT-3 Double Nickase Plasmid (m2) - sc-428711-NIC-2 from Santa Cruz Biotechnology
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NMNAT-3 CRISPR Activation Plasmid (m) - sc-428711-ACT from Santa Cruz Biotechnology
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NMNAT-3 CRISPR Activation Plasmid (m2) - sc-428711-ACT-2 from Santa Cruz Biotechnology
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NMNAT-3 Lentiviral Activation Particles (m) - sc-428711-LAC from Santa Cruz Biotechnology
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NMNAT-3 Lentiviral Activation Particles (m2) - sc-428711-LAC-2 from Santa Cruz Biotechnology
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NMNAT-3 siRNA (m) - sc-62696 from Santa Cruz Biotechnology
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NMNAT-3 shRNA Plasmid (m) - sc-62696-SH from Santa Cruz Biotechnology
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NMNAT-3 shRNA (m) Lentiviral Particles - sc-62696-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU020201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN36536 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36536 from Sigma-Aldrich
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NMNAT3 siRNA (Mouse) - CRM9103 from Cohesion Biosciences
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shRNA set against Mouse NMNAT3 (NM_144533.2) - SHH353252 from Creative biogene
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shRNA set against Mouse Nmnat3(NM_144533.2) - SHR014268 from Creative biogene
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Mouse NMNAT3 siRNA - orb288579 from Biorbyt
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NMNAT3 shRNA Plasmid (Mouse) - CHM9103 from Cohesion Biosciences
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NMNAT3 miRNA 3'UTR clone - MiUTR1M-07711 from Creative biogene
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