TET2

Gene Symbol	TET2
Entrez Gene	54790
Alt Symbol	KIAA1546, MDS
Species	Human
Gene Type	protein-coding
Description	tet methylcytosine dioxygenase 2
Other Description	methylcytosine dioxygenase TET2|probable methylcytosine dioxygenase TET2|tet oncogene family member 2
Swissprots	Q9NXW0 Q96JX5 B5MDU0 Q9HCM6 Q6N021 Q3LIB8 Q2TB88
Accessions	EAX06177 EAX06178 EAX06179 Q6N021 AB046766 BAB13372 AB075496 BAE45750 AI084057 AK000039 BAA90898 AK027819 BAB55391 AK055149 BC019007 BC110509 AAI10510 BC110510 AAI10511 BC150180 AAI50181 BC150201 AAI50202 BQ006500 BX640738 CAE45851 DA391215 DR000714 DR005542 FM992369 CAX30492 XM_005263082 XP_005263139 XM_006714242 XP_006714305 XM_011532043 XP_011530345 XM_011532044 XP_011530346 XR_244633 XR_244634 XR_427546 XR_938746 XR_938747 NM_001127208 NP_001120680 NM_017628 NP_060098
Function	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889,
Tissue Specificity	Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes. {ECO:0000269|PubMed:12646957, ECO:0000269|PubMed:19483684}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Tet2 protein fragment - ab172186 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Tet2 peptide - ab106206 from Abcam Category Peptide

TET2 Antibody Blocking Peptide - LS-E4977 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TET2 Antibody Blocking Peptide - LS-E27733 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TET2 Antibody Blocking Peptide - LS-E27174 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TET2 Antibody Blocking Peptide - LS-E31290 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TET2-Antibody-N-term-Blocking-Peptide - BP17372a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TET2 blocking peptide - GTX88329-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog

Tet2 Peptide - AC21-1994-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TET2 (N-term) Control Peptide - AP55673CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TET2 Peptide - 42-198P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

TET2 Peptide - 6915P from ProSci Category Peptide Species Human

TET2 fusion protein - Ag15583 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TET2 fusion protein - Ag15773 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human TET2, GST-tagged - TET2-160H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human TET2, GST-tagged - TET2-3184H from Creative Biomart Category Protein Source E.coli Species Human

TET2 protein-GST fusion - 009-001-U14 from Rockland Immunochemicals Inc Category Protein Prices $599.00 Sizes 50 µg Species Human

TET2 protein-GST fusion - 009-001-U14S from Rockland Immunochemicals Inc Category Protein Prices $315.00 Sizes 20 µg Species Human

Recombinant Human Methylcytosine dioxygenase TET2(TET2) ,partial - CSB-YP764560HU CSB-EP764560HU CSB-BP764560HU CSB-MP764560HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Tet2 (1129-2002) protein - 31418 from ActiveMotif Category Protein Prices $415.00 Sizes 10 µg Source Baculovirus Species Human

DiMethyl-TET2-R1682 Peptide - abx165207 from Abbexa Category Peptide Species Human

TET2, Recombinant Protein - MBS515384 from MyBioSource Category Protein Prices $325.00, $500.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

TET2 , Peptide - MBS426378 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog

TET2 Peptide, Human - M34GP15805H from Creative Peptides Category Peptide Source Synthetic. Species Human

Methylcytosine dioxygenase TET2 (TET2), partial, Recombinant Protein - MBS1445282 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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