TET2

Gene Symbol	TET2
Entrez Gene	54790
Alt Symbol	KIAA1546, MDS
Species	Human
Gene Type	protein-coding
Description	tet methylcytosine dioxygenase 2
Other Description	methylcytosine dioxygenase TET2|probable methylcytosine dioxygenase TET2|tet oncogene family member 2
Swissprots	Q9NXW0 Q96JX5 B5MDU0 Q9HCM6 Q6N021 Q3LIB8 Q2TB88
Accessions	EAX06177 EAX06178 EAX06179 Q6N021 AB046766 BAB13372 AB075496 BAE45750 AI084057 AK000039 BAA90898 AK027819 BAB55391 AK055149 BC019007 BC110509 AAI10510 BC110510 AAI10511 BC150180 AAI50181 BC150201 AAI50202 BQ006500 BX640738 CAE45851 DA391215 DR000714 DR005542 FM992369 CAX30492 XM_005263082 XP_005263139 XM_006714242 XP_006714305 XM_011532043 XP_011530345 XM_011532044 XP_011530346 XR_244633 XR_244634 XR_427546 XR_938746 XR_938747 NM_001127208 NP_001120680 NM_017628 NP_060098
Function	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. {ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493, ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540, ECO:0000269|PubMed:23353889,
Tissue Specificity	Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes. {ECO:0000269|PubMed:12646957, ECO:0000269|PubMed:19483684}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TET2 (C-7) - sc-398535 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TET2 (S-13) - sc-136926 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-Tet2 antibody - ab94580 from Abcam Prices $398.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Tet2 antibody - ab135062 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Tet2 antibody - ab135087 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Tet2 antibody - ab99432 from Abcam Prices $370.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-Tet2 antibody - ab125048 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (aa761-775) - LS-C112875 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-TET2 Antibody (aa254-267) - LS-C154860 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-TET2 Antibody (aa528-554, AP) - LS-C224297 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (aa528-554, APC) - LS-C224298 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (aa528-554, Biotin) - LS-C224300 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (aa528-554, PE) - LS-C224301 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (aa528-554, Azide-free, HRP) - LS-C224302 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (aa528-554, FITC) - LS-C224304 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (aa527-554) - LS-C325670 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody - LS-C341814 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (N-Terminus) - LS-C153760 from LifeSpan Bioscience Prices $325.00, $890.00 Sizes 100 µg, 500 µg Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody - LS-C331509 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (aa528-554) - LS-C157167 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody - LS-C334211 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (C-Terminus) - LS-C336148 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TET2 Antibody (aa100-150) - LS-C290887 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TET2 Antibody - NBP2-32104 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TET2 Antibody - NBP2-27465 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

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