BBS1

Gene Symbol	BBS1
Entrez Gene	582
Alt Symbol	BBS2L2
Species	Human
Gene Type	protein-coding
Description	Bardet-Biedl syndrome 1
Other Description	BBS2-like protein 2|Bardet-Biedl syndrome 1 protein
Swissprots	Q8NFJ9 Q32MN0 Q96SN4 Q32MM9
Accessions	CDI06878 EAW74542 Q8NFJ9 AF503941 AAM92770 AK027243 BAB15704 AK095638 AK294962 BAG58036 AK296311 BAG59009 AK302657 BAG63895 BC047642 AAH47642 BC109064 AAI09065 BC109065 AAI09066 BX647612 CAI46060 NM_024649 NP_078925
Function	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.
Subcellular Location	Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Tissue Specificity	Highly expressed in the kidney. Also found in fetal tissue, testis, retina, adipose tissue, heart, skeletal muscle and pancreas.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BBS1 (F-1) - sc-365138 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

BBS1 (E-14) - sc-49789 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

BBS1 (N-20) - sc-49790 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

BBS1 (H-300) - sc-134455 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

BBS1 (S-19) - sc-49791 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-BBS1 antibody - ab121015 from Abcam Prices $242.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-BBS1 antibody - ab194412 from Abcam Prices $370.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-BBS1 antibody [EPR7906] - ab166613 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7906

Anti-BBS1 Antibody (aa269-283) - LS-C154816 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-BBS1 Antibody (aa110-159) - LS-C135458 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

BBS1 Antibody - NBP2-34106 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

BBS1 Antibody - H00000582-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

BBS1 Polyclonal Antibody - bs-11507R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11507R-A350 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11507R-A488 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11507R-A555 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11507R-A647 from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, Cy3 Conjugated - bs-11507R-Cy3 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, Cy5 Conjugated - bs-11507R-Cy5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, Cy5.5 Conjugated - bs-11507R-Cy5.5 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, Cy7 Conjugated - bs-11507R-Cy7 from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, FITC Conjugated - bs-11507R-FITC from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, Biotin Conjugated - bs-11507R-Biotin from Bioss Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-BBS1 Polyclonal Antibody, HRP Conjugated - bs-11507R-HRP from Bioss Prices $345.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BBS1 antibody produced in rabbit - HPA058283 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Search more