BBS1

Gene Symbol	BBS1
Entrez Gene	582
Alt Symbol	BBS2L2
Species	Human
Gene Type	protein-coding
Description	Bardet-Biedl syndrome 1
Other Description	BBS2-like protein 2|Bardet-Biedl syndrome 1 protein
Swissprots	Q8NFJ9 Q32MN0 Q96SN4 Q32MM9
Accessions	CDI06878 EAW74542 Q8NFJ9 AF503941 AAM92770 AK027243 BAB15704 AK095638 AK294962 BAG58036 AK296311 BAG59009 AK302657 BAG63895 BC047642 AAH47642 BC109064 AAI09065 BC109065 AAI09066 BX647612 CAI46060 NM_024649 NP_078925
Function	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.
Subcellular Location	Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Tissue Specificity	Highly expressed in the kidney. Also found in fetal tissue, testis, retina, adipose tissue, heart, skeletal muscle and pancreas.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BBS1 full length protein - ab157954 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human BBS1 protein fragment - ab157955 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BBS1 Antibody Blocking Peptide - LS-E27566 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BBS1 Antibody Blocking Peptide - LS-E21055 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human BBS1 Protein - H00000582-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human BBS1 Protein - H00000582-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Bbs1 Blocking Peptide - 33R-7002 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BBS1 / BBS2L2 - H00000582-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

BBS1 / BBS2L2 - H00000582-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BBS1 / BBS2L2 - H00000582-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BBS1 fusion protein - ag15460 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

BBS1 fusion protein - ag15557 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Bardet-Biedl syndrome 1 protein(BBS1) - CSB-YP836736HU CSB-EP836736HU CSB-BP836736HU CSB-MP836736HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BBS1 Recombinant Protein Antigen - NBP2-34106PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

BBS1 Peptide, Human - M34GP01340H from Creative Peptides Category Peptide Source Synthetic. Species Human

Bardet-Biedl syndrome 1 protein (BBS1), Recombinant Protein - MBS1354426 from MyBioSource Category Protein Prices $1,395.00, $1,395.00, $1,610.00, $1,610.00, $2,325.00, $2,325.00, $2,770.00, $2,770.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Bbs1 Immunizing peptide - orb59726 from Biorbyt Category Peptide

Recombinant Human BBS1 Protein, GST-tagged - BBS1-104H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human BBS1 Protein, GST-tagged - BBS1-105H from Creative Biomart Category Protein Source Wheat Germ Species Human

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