PKM

Gene Symbol	PKM
Entrez Gene	5315
Alt Symbol	CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1
Species	Human
Gene Type	protein-coding
Description	pyruvate kinase, muscle
Other Description	OIP-3|OPA-interacting protein 3|PK, muscle type|cytosolic thyroid hormone-binding protein|epididymis secretory protein Li 30|p58|pyruvate kinase 2/3|pyruvate kinase PKM|pyruvate kinase isozymes M1/M2|pyruvate kinase muscle isozyme|thyroid hormone-binding protein 1|thyroid hormone-binding protein, cytosolic|tumor M2-PK
Swissprots	Q53GK4 B2R5N8 Q9UCV6 B4DFX8 Q9UPF2 P14786 A6NFK3 B4DUU6 Q9BWB5 Q96E76 P14618 B3KRY0
Accessions	AAD47248 AAD47249 AAF01766 AAF65764 AAQ15274 CAA39849 EAW77884 EAW77885 EAW77886 EAW77887 EAW77888 EAW77889 EAW77890 P14618 AF025439 AAC39559 AK092369 BAG52542 AK222927 BAD96647 AK294315 BAG57589 AK297951 BAG60266 AK299413 BAG61395 AK300800 BAG62458 AK307855 AK308264 AK309781 AK312253 BAG35185 BC000481 AAH00481 BC007640 AAH07640 BC007952 AAH07952 BC012811 AAH12811 BC019265 AAH19265 BC023328 BC023592 BC035198 AAH35198 BC035487 BC094767 AAH94767 BC096823 BG490968 BX648597 DA382029 DC376054 DQ892739 ABM83665 EU176742 ABW03543 EU794631 ACJ13685 EU832358 ACE87615 EU832443 ACE86928 M23725 AAA36449 M26252 AAA36672 Z36786 Z36831 XM_005254443 XP_005254500 XM_005254445 XP_005254502 XM_006720570 XP_006720633 XM_011521670 XP_011519972 XM_011521671 XP_011519973 XM_011521672 XP_011519974 XM_011521673 XP_011519975 NM_001206796 NP_001193725 NM_001206797 NP_001193726 NM_001206798 NP_001193727 NM_001206799 NP_001193728 NM_002654 NP_002645 NM_182470 NP_872270 NM_182471 NP_872271
Function	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. {ECO:0000269|PubMed:17308100, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:21620138}.
Subcellular Location	Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.
Tissue Specificity	Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. {ECO:0000269|PubMed:18191611}.
Top Pathways	Viral carcinogenesis, Glycolysis / Gluconeogenesis, Type II diabetes mellitus, Central carbon metabolism in cancer, Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKM2 full length protein - ab89364 from Abcam Category Protein Prices $200.00, $706.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Active human PKM2 full length protein - ab168037 from Abcam Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

Active human Pyruvate kinase isozyme M1 full length protein - ab196081 from Abcam Category Protein Prices $837.00 Sizes 20 µg Source E. coli Species Human

Active mouse PKM2 full length protein - ab95474 from Abcam Category Protein Prices $492.00 Sizes 20 µg Source E. coli Species Mouse

Human PKM2 full length protein - ab178466 from Abcam Category Protein Source E. coli Species Human

Human PKM2 full length protein - ab53384 from Abcam Category Protein Source E. coli Species Human

Human PKM2 peptide - ab94378 from Abcam Category Peptide

PKM / Pyruvate Kinase Antibody Blocking Peptide - LS-E8740 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKM / Pyruvate Kinase Antibody Blocking Peptide - LS-E8741 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKM / Pyruvate Kinase Antibody Blocking Peptide - LS-E8638 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKM / Pyruvate Kinase Antibody Blocking Peptide - LS-E21117 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKM / Pyruvate Kinase Antibody Blocking Peptide - LS-E21118 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKM / Pyruvate Kinase Antibody Blocking Peptide - LS-E8994 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKM / Pyruvate Kinase Antibody Blocking Peptide - LS-E8637 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKM / Pyruvate Kinase Antibody Blocking Peptide - LS-E9926 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKM2 Blocking Peptide - NBP1-48308PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µl

PKM2 Partial Recombinant Protein - H00005315-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PKM2 Recombinant Protein - H00005315-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human PKM2 Protein - NBP1-30292 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Recombinant Human PKM2 Protein - H00005315-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PKM2 Peptide - P2141 from Novus Biologicals Category Peptide Species Human

PKM2 Peptide - P2140 from Novus Biologicals Category Peptide Species Human

Pyruvate-Kinase-PKM2-Antibody-C-term-Blocking-peptide - BP7044b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Pyruvate-Kinase-PKM2-Antibody-N-term-Blocking-peptide - BP7044a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PKM2-Antibody-C-term-L398-Blocking-Peptide - BP7173d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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