Gene Symbol | DMBX1 |
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Entrez Gene | 127343 |
Alt Symbol | MBX, OTX3, PAXB |
Species | Human |
Gene Type | protein-coding |
Description | diencephalon/mesencephalon homeobox 1 |
Other Description | diencephalon/mesencephalon homeobox protein 1|homeoprotein MBX|orthodenticle homolog 3|paired-like homeobox protein DMBX1 |
Swissprots | Q8NFW6 Q8NHD9 Q8NFW5 A6NNN2 |
Accessions | EAX06907 Q8NFW5 AB037699 BAC00920 AF398527 AAM90589 AF398528 AAM90590 AY726596 BC156064 AAI56065 BC156881 AAI56882 XM_011540667 XP_011538969 XM_011540668 XP_011538970 XM_011540669 XP_011538971 XM_011540670 XP_011538972 NM_147192 NP_671725 NM_172225 NP_757379 |
Function | Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250|UniProtKB:O35137, ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE- ProRule:PRU00138}. |
OTX3 CRISPR/Cas9 KO Plasmid (h) - sc-414300 from Santa Cruz Biotechnology
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OTX3 HDR Plasmid (h) - sc-414300-HDR from Santa Cruz Biotechnology
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OTX3 Double Nickase Plasmid (h) - sc-414300-NIC from Santa Cruz Biotechnology
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OTX3 Double Nickase Plasmid (h2) - sc-414300-NIC-2 from Santa Cruz Biotechnology
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OTX3 CRISPR Activation Plasmid (h) - sc-414300-ACT from Santa Cruz Biotechnology
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OTX3 CRISPR Activation Plasmid (h2) - sc-414300-ACT-2 from Santa Cruz Biotechnology
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OTX3 Lentiviral Activation Particles (h) - sc-414300-LAC from Santa Cruz Biotechnology
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OTX3 Lentiviral Activation Particles (h2) - sc-414300-LAC-2 from Santa Cruz Biotechnology
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OTX3 siRNA (h) - sc-61271 from Santa Cruz Biotechnology
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OTX3 shRNA Plasmid (h) - sc-61271-SH from Santa Cruz Biotechnology
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OTX3 shRNA (h) Lentiviral Particles - sc-61271-V from Santa Cruz Biotechnology
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OTX3 RNAi - H00127343-R02 from Novus Biologicals
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OTX3 RNAi - H00127343-R01 from Novus Biologicals
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MISSION® esiRNA - EHU076861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7308 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7308 from Sigma-Aldrich
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DMBX1 siRNA (Human) - CRJ4912 from Cohesion Biosciences
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DMBX1 - MBS8225127 from MyBioSource
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shRNA set against Human DMBX1 (NM_147192.2) - SHH278761 from Creative biogene
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shRNA set against Human DMBX1(NM_147192.2) - SHH007769 from Creative biogene
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shRNA set against Human DMBX1(NM_172225.1) - SHH007823 from Creative biogene
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Human DMBX1 siRNA - orb275413 from Biorbyt
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DMBX1 shRNA Plasmid (Human) - CHJ4912 from Cohesion Biosciences
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DMBX1 miRNA 3'UTR clone - MiUTR1H-02880 from Creative biogene
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DMBX1 miRNA 3'UTR clone - MiUTR1H-02881 from Creative biogene
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