| Gene Symbol |
USP37
|
| Entrez Gene |
57695
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 37
|
| Other Description |
deubiquitinating enzyme 37|tmp_locus_50|ubiquitin carboxyl-terminal hydrolase 37|ubiquitin specific protease 37|ubiquitin thioesterase 37|ubiquitin thiolesterase 37|ubiquitin-specific-processing protease 37
|
| Swissprots |
B7ZM41 Q2KHT2 Q9HCH8 Q7Z3A5 Q53S10 B7ZM38 A2RUQ8 E9PHL3 Q86T82
|
| Accessions |
AAY14887 EAW70621 EAW70622 EAW70623 Q86T82 AB046814 BAB13420 AK095577 AK128583 AL832645 CAD89955 AM392929 CAL37807 AM393416 CAL38294 BC037389 BC050461 AAH50461 BC112901 AAI12902 BC133007 AAI33008 BC133009 AAI33010 BC144249 AAI44250 BC144252 AAI44253 BX538024 CAD97970 DB075170 XM_005246720 XP_005246777 XM_005246721 XP_005246778 XM_005246722 XP_005246779 XM_005246724 XP_005246781 XM_011511538 XP_011509840 XM_011511539 XP_011509841 XM_011511540 XP_011509842 XM_011511541 XP_011509843 XM_011511542 XP_011509844 XR_922975 NM_020935 NP_065986
|
| Function |
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). {ECO:0000269|PubMed:21596315}.
|
| Tissue Specificity |
Expressed in brain and prostate. {ECO:0000269|PubMed:14715245}.
|