LRRC8A

Gene Symbol	LRRC8A
Entrez Gene	56262
Alt Symbol	AGM5, LRRC8, SWELL1
Species	Human
Gene Type	protein-coding
Description	leucine rich repeat containing 8 family, member A
Other Description	leucine-rich repeat-containing protein 8A|swelling protein 1|volume-regulated anion channel subunit LRRC8A
Swissprots	Q8NCI0 Q9P2B1 Q8IWT6 Q6UXM2
Accessions	EAW87842 EAW87843 Q8IWT6 AB037858 BAA92675 AK001199 BAA91549 AK024649 AK027495 BAB55153 AK074723 BAC11161 AK123611 AK289842 BAF82531 AY143166 AAN18279 AY358286 AAQ88653 BC000775 BC051322 AAH51322 BX376144 CA446287 DA243590 XM_005252095 XP_005252152 XM_005252096 XP_005252153 XM_006717186 XP_006717249 XM_011518863 XP_011517165 XM_011518864 XP_011517166 XM_011518865 XP_011517167 NM_001127244 NP_001120716 NM_001127245 NP_001120717 NM_019594 NP_062540
Function	Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development. {ECO:0000269|PubMed:14660746, ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24790029}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029}; Multi- pass membrane protein {ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029}.
Tissue Specificity	Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells. Expressed on T-cells as well as on B-lineage cells. {ECO:0000269|PubMed:10718198, ECO:0000269|PubMed:14660746}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LRRC8A protein fragment - ab163372 from Abcam Category Protein Source Wheat germ Species Human

LRRC8A / LRRC8 Antibody Blocking Peptide - LS-E6689 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LRRC8A / LRRC8 Antibody Blocking Peptide - LS-E17848 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LRRC8A Protein - H00056262-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LRRC8A-AntibodyC-term-Blocking-peptide - BP19519b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LRRC8A Blocking Peptide - 33R-6781 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LRRC8A Blocking Peptide - 33R-4105 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LRRC8A - H00056262-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LRRC8A - H00056262-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

LRRC8A Peptide - 8235P from ProSci Category Peptide Species Human

LRRC8A fusion protein - Ag10062 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

LRRC8A fusion protein - ag10889 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

LRRC8A (transcript variant 2) - TP308632 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

LRRC8A (transcript variant 1) - TP326180 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

LRRC8A (transcript variant 3) - TP326181 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

LRRC8A Recombinant Protein Antigen - NBP1-84636PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

LRRC8A Peptide, Human - M34GP08929H from Creative Peptides Category Peptide Source Synthetic. Species Human

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