LRRC8A

Gene Symbol	LRRC8A
Entrez Gene	56262
Alt Symbol	AGM5, LRRC8, SWELL1
Species	Human
Gene Type	protein-coding
Description	leucine rich repeat containing 8 family, member A
Other Description	leucine-rich repeat-containing protein 8A|swelling protein 1|volume-regulated anion channel subunit LRRC8A
Swissprots	Q8NCI0 Q9P2B1 Q8IWT6 Q6UXM2
Accessions	EAW87842 EAW87843 Q8IWT6 AB037858 BAA92675 AK001199 BAA91549 AK024649 AK027495 BAB55153 AK074723 BAC11161 AK123611 AK289842 BAF82531 AY143166 AAN18279 AY358286 AAQ88653 BC000775 BC051322 AAH51322 BX376144 CA446287 DA243590 XM_005252095 XP_005252152 XM_005252096 XP_005252153 XM_006717186 XP_006717249 XM_011518863 XP_011517165 XM_011518864 XP_011517166 XM_011518865 XP_011517167 NM_001127244 NP_001120716 NM_001127245 NP_001120717 NM_019594 NP_062540
Function	Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development. {ECO:0000269|PubMed:14660746, ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24790029}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029}; Multi- pass membrane protein {ECO:0000269|PubMed:24725410, ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029}.
Tissue Specificity	Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells. Expressed on T-cells as well as on B-lineage cells. {ECO:0000269|PubMed:10718198, ECO:0000269|PubMed:14660746}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LRRC8A (T-16) - sc-163042 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LRRC8A (N-14) - sc-163041 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-LRRC8A antibody - C-terminal - ab174352 from Abcam Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa782-810, FITC) - LS-C262262 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa782-810, Biotin) - LS-C262261 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa782-810, AP) - LS-C262259 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa782-810, APC) - LS-C262260 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa782-810, Azide-free, HRP) - LS-C262263 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa782-810, PE) - LS-C262264 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa50-100) - LS-C286193 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa650-700) - LS-C290816 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa782-810) - LS-C322743 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (C-Terminus) - LS-C107650 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (N-Terminus) - LS-C81385 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa760-810) - LS-C290818 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa648-803) - LS-C179163 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LRRC8A / LRRC8 Antibody (aa782-810) - LS-C157873 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

LRRC8A Antibody - NBP1-59493 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LRRC8A Antibody - NBP1-59538 from Novus Biologicals Prices $369.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

LRRC8A Antibody - NBP2-32158 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LRRC8A Antibody - NBP1-84636 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LRRC8A Antibody - NBP2-32082 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LRRC8A Antibody - NBP2-32081 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LRRC8A Antibody (8H9) - H00056262-M04-100ug from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 8H9

Monoclonal Anti-LRRC8A antibody produced in mouse - SAB1412855 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 8H9

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