Gene Symbol |
WIPF2
|
Entrez Gene |
147179
|
Alt Symbol |
WICH, WIRE
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
WAS/WASL interacting protein family, member 2
|
Other Description |
WAS/WASL-interacting protein family member 2|WASP-binding protein|WASP-interacting protein-related protein|WIP- and CR16-homologous protein|WIP-related protein
|
Swissprots |
Q8TF74 Q8TE44 Q71RE1 Q658J8 A8K0L3
|
Accessions |
EAW60648 EAW60649 Q8TF74 AB043786 BAB85113 AF370396 AAQ15232 AJ431177 CAD24007 AK026913 AK055025 AK055057 BAG51456 AK289578 BAF82267 AK289779 BAF82468 AK290301 BAF82990 AK311544 AK315836 BAF98727 AL834239 CAH56360 AU138315 BC019706 BC025965 BC030561 BC043408 BC047435 BC064504 BC065551 AAH65551 CB240594 CN404607 DQ586635 U90911 XM_005257083 XP_005257140 XM_005257084 XP_005257141 XM_011524412 XP_011522714 XM_011524413 XP_011522715 NM_133264 NP_573571
|
Function |
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}.
|
Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. Note=Localized to stress fibers and bundles of actin filaments.
|
Tissue Specificity |
Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta. {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}.
|