Gene Symbol | SPG7 |
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Entrez Gene | 6687 |
Alt Symbol | CAR, CMAR, PGN, SPG5C |
Species | Human |
Gene Type | protein-coding |
Description | spastic paraplegia 7 (pure and complicated autosomal recessive) |
Other Description | cell matrix adhesion regulator|paraplegin|spastic paraplegia 7 protein |
Swissprots | Q2TB70 O75756 Q96IB0 Q9UQ90 Q58F00 |
Accessions | AAD28099 BAA03160 CAA46667 EAW66726 EAW66727 EAW66728 EAW66729 Q9UQ90 AF034795 AAC02429 AF090912 AAF24033 AK094627 BAG52898 AW250773 BC007692 BC015411 BC035929 AAH35929 BC036104 AAH36104 BC052587 BI827568 CA447374 DA770435 DB482451 EU832769 ACE87780 GQ129312 ACT64446 HY006239 S54769 AAB25303 Y16610 CAA76314 Z35498 XM_005256321 XP_005256378 XM_006721264 XP_006721327 XM_011523306 XP_011521608 XM_011523307 XP_011521609 NM_003119 NP_003110 NM_199367 NP_955399 |
Function | Putative ATP-dependent zinc metalloprotease. |
Subcellular Location | Mitochondrion membrane {ECO:0000269|PubMed:9635427}; Multi-pass membrane protein {ECO:0000269|PubMed:9635427}. |
Tissue Specificity | Ubiquitous. |
Paraplegin CRISPR/Cas9 KO Plasmid (h) - sc-406299 from Santa Cruz Biotechnology
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Paraplegin HDR Plasmid (h) - sc-406299-HDR from Santa Cruz Biotechnology
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Paraplegin Double Nickase Plasmid (h) - sc-406299-NIC from Santa Cruz Biotechnology
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Paraplegin Double Nickase Plasmid (h2) - sc-406299-NIC-2 from Santa Cruz Biotechnology
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Paraplegin CRISPR Activation Plasmid (h) - sc-406299-ACT from Santa Cruz Biotechnology
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Paraplegin CRISPR Activation Plasmid (h2) - sc-406299-ACT-2 from Santa Cruz Biotechnology
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Paraplegin Lentiviral Activation Particles (h) - sc-406299-LAC from Santa Cruz Biotechnology
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Paraplegin Lentiviral Activation Particles (h2) - sc-406299-LAC-2 from Santa Cruz Biotechnology
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Paraplegin siRNA (h) - sc-62755 from Santa Cruz Biotechnology
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Paraplegin shRNA Plasmid (h) - sc-62755-SH from Santa Cruz Biotechnology
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Paraplegin shRNA (h) Lentiviral Particles - sc-62755-V from Santa Cruz Biotechnology
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SPG7 RNAi - H00006687-R03 from Novus Biologicals
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SPG7 RNAi - H00006687-R04 from Novus Biologicals
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MISSION® esiRNA - EHU093351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20464 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20464 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07112 from Sigma-Aldrich
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SPG7 siRNA (Human) - CRH4557 from Cohesion Biosciences
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SPG7 - MBS8213202 from MyBioSource
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Paraplegin CRISPR/Cas9 KO Plasmid (h2) - sc-406299-KO-2 from Santa Cruz Biotechnology
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Paraplegin HDR Plasmid (h2) - sc-406299-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human SPG7 (NM_003119.2) - SHH416588 from Creative biogene
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shRNA set against Human SPG7(NM_003119.2) - SHL028240 from Creative biogene
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shRNA set against Human SPG7(NM_199367.1) - SHL028422 from Creative biogene
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SPG7 shRNA Plasmid (Human) - CHH4557 from Cohesion Biosciences
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