SPG7

Gene Symbol SPG7
Entrez Gene 6687
Alt Symbol CAR, CMAR, PGN, SPG5C
Species Human
Gene Type protein-coding
Description spastic paraplegia 7 (pure and complicated autosomal recessive)
Other Description cell matrix adhesion regulator|paraplegin|spastic paraplegia 7 protein
Swissprots Q2TB70 O75756 Q96IB0 Q9UQ90 Q58F00
Accessions AAD28099 BAA03160 CAA46667 EAW66726 EAW66727 EAW66728 EAW66729 Q9UQ90 AF034795 AAC02429 AF090912 AAF24033 AK094627 BAG52898 AW250773 BC007692 BC015411 BC035929 AAH35929 BC036104 AAH36104 BC052587 BI827568 CA447374 DA770435 DB482451 EU832769 ACE87780 GQ129312 ACT64446 HY006239 S54769 AAB25303 Y16610 CAA76314 Z35498 XM_005256321 XP_005256378 XM_006721264 XP_006721327 XM_011523306 XP_011521608 XM_011523307 XP_011521609 NM_003119 NP_003110 NM_199367 NP_955399
Function Putative ATP-dependent zinc metalloprotease.
Subcellular Location Mitochondrion membrane {ECO:0000269|PubMed:9635427}; Multi-pass membrane protein {ECO:0000269|PubMed:9635427}.
Tissue Specificity Ubiquitous.

Paraplegin (C-5) - sc-514393 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Paraplegin (C-5): sc-514393. Western blot analysis of Paraplegin expression in HeLa (A), Hep G2 (B) and JAR (C) whole cell lysates.

Paraplegin (G-16) - sc-55976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Paraplegin (S-12) - sc-55978 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Paraplegin (H-180) - sc-135026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Paraplegin (H-180): sc-135026. Western blot analysis of Paraplegin expression in rat skeletal muscle tissue extract (A) and human recombinant Paraplegin fusion protein (B).

Paraplegin (A-19) - sc-55975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Paraplegin (A-19): sc-55975. Western blot analysis of Paraplegin expression in A-431 whole cell lysate.

Anti-SPG7 antibody - ab154989 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SPG7 antibody (ab154989) at 1 µg/mlLane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : Spinal Cord (Human) Tissue Lysate - adult normal tissue (ab29188)Lane 3 : Spinal Cord (Mouse) Tissue LysateLane 4 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/50000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SPG7 antibody - ab72424 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SPG7 antibody (ab72424)Lane 1 : SPG7 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysate

Anti-SPG7 antibody - ab73008 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SPG7 antibody (ab73008) at 1/500 dilutionLane 1 : SPG7 transfected 293T cell lysate Lane 2 : Non transfected 293T cell lysate Lysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-SPG7 antibody [1G4] - ab156950 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G4
All lanes : Anti-SPG7 antibody [1G4] (ab156950) at 1/2000 dilutionLane 1 : Negative control E.coli lysate Lane 2 : E.coli lysate containing recombinant fragment of Human SPG7 (amino acids 300-573)Lysates/proteins at 5 µg per lane.

Anti-Paraplegin / SPG7 Antibody (aa300-573, clone 1C1) - LS-C337663 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C1
Anti-SPG7 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SPG7.

Anti-Paraplegin / SPG7 Antibody (clone 9F12) - LS-C175080 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9F12
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SPG7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SPG7.

Anti-Paraplegin / SPG7 Antibody (clone 1D2) - LS-C173806 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D2
Negative control E. coli lysate (Left lane) or E. coli lysate containing recombinant protein fragment for human SPG7(NP_003110) gene (amino acids 300-573) (Right lane). Equivalent amounts (5 ug per lane) were separated by SDS-PAGE and then immunoblotted with anti-SPG7. .

Anti-Paraplegin / SPG7 Antibody (aa114-141, AP) - LS-C270181 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Paraplegin / SPG7 Antibody (aa114-141) - LS-C161447 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SPG7 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-Paraplegin / SPG7 Antibody (aa114-141, APC) - LS-C270182 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Paraplegin / SPG7 Antibody (aa114-141, Biotin) - LS-C270183 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Paraplegin / SPG7 Antibody (aa114-141, Azide-free, HRP) - LS-C270184 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Paraplegin / SPG7 Antibody (clone 5H7) - LS-C175083 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5H7
Anti-SPG7 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SPG7.

Anti-Paraplegin / SPG7 Antibody (aa114-141, FITC) - LS-C270185 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Paraplegin / SPG7 Antibody (clone 1D10) - LS-C175078 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D10
Anti-SPG7 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SPG7.

Anti-Paraplegin / SPG7 Antibody (aa114-141, PE) - LS-C270186 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Paraplegin / SPG7 Antibody (aa114-141) - LS-C325327 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Paraplegin / SPG7 Antibody (clone 3E8) - LS-C175081 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E8
Anti-SPG7 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SPG7.

Anti-Paraplegin / SPG7 Antibody (clone 1H4) - LS-C175079 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H4
Anti-SPG7 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SPG7.

Anti-Paraplegin / SPG7 Antibody (aa384-598) - LS-C186381 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (50 ug of whole cell lysate). A: Mouse brain. 7.5% SDS PAGE. Paraplegin / SPG7 antibody diluted at 1:1000.
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